...Great. Thanks very much, everybody, for those who continue to dial into the fireside chat this afternoon. I am happy to be moderating a discussion here with executives from Ionis Pharmaceuticals. With me, we have CEO, Brett Monia; and CFO, Beth Hougen, who I'm sure folks style they know quite well. Maybe we can start and just have Brett give a 3 to 5-minute overview, set the stage for Ionis' key pipeline events coming off recent progress, and then we can get into Q&A. How does that sound? Brett P. Monia ...