...Hi there, everyone. My name is Tyler Van Buren, I'm a senior biotech analyst at Piper Sandler. Welcome to Piper's 32nd Annual Healthcare Conference. As this is our first time with a virtual format, we appreciate you all logging in. For this session, we're very pleased to have Ionis Pharmaceuticals here with us. And from Ionis, we have Brett Monia, the Chief Executive Officer; and Beth Hougen, the Chief Financial Officer. So I figured we could start with a brief state of the union of the company and the description of the science behind the drugs for those who are less familiar, which by now, I'm sure it's not many. But also, it would be helpful to explain why you guys are so committed to the antisense technology and what indications it could be used for. Brett P. Monia ...