...Unidentified Company Representative It is my pleasure to present the results from the ongoing REC-4881 201 trial and our FAP natural history analysis. So let's start by reviewing some background on FAP so we can better understand the significance of our results. Familial Adenomatous Polyposis is a rare orphan disease caused by autosomal dominant mutations in the APC gene. As a result of this loss of APC, patients will develop hundreds of thousands of adenomas or polyps in their colon and rectum by their late 10s and early 20s. In the absence of surgery, these patients have a 100% risk of developing colorectal cancer by the age of 40. These precancerous adenomas progressively accumulate, and there is little evidence of spontaneous regression. As Najat mentioned, currently, there are no approved pharmacotherapies for FAP. Patients face a lifetime of endoscopic surveillance, frequent excisional interventions, and life altering surgeries that impact quality of life, morbidity, and long-term...
