...Great. Continuing with the theme of Oligos in CNS. It's my pleasure to be moderating a panel with Holly Kordasiewicz, who is the Senior Vice President of the Neurology Group at Ionis, along with Wade Walke, Senior Director, VP of Investor Relations. So good to see both of you this morning. I think instead of like I think most folks are well aware of Ionis is like overarching efforts and the great success you guys have had in CNS. So I thought it would be interesting would be to maybe just go through program by program, I'm super interested in the Angelman's program, super excited in tau, some of the other ALS targets you're looking at. And so if that works for you, maybe we can just get into it. Holly Kordasiewicz ...