...Great. Thanks so much, everybody. It's my pleasure to be hosting this panel with Frank Bennett, an R&D leader at Ionis, and also one of the experts in neuroscience and neurology drug development. And he's been kind enough to join this conference every year. So I really appreciate it, Frank, for you coming today. On that note, I was maybe just kind of hoping you could start, Frank, and give an overview of the various clinical-stage assets that Ionis has in development for CNS. And then naturally, we can get into Q&A and more of a discussion. So thanks again. C. Frank Bennett ...