...Jennifer Capuzelo Good morning. I'm Jennifer Capuzelo, Director of Investor Relations, and I'd like to welcome you to the Ionis 2021 Investor Day. Following our prepared remarks today, we will host a question-and-answer session. (Operator Instructions) Additionally, today's presentation is being recorded, and a replay will be available on the Ionis website shortly. Before we continue, please be aware that during today's presentation, we will be making forward-looking statements, which are based on our current expectations and beliefs. Please consult the risk factors discussed in our SEC filings for additional detail. And with that, I'll turn it over to CEO, Brett Monia. Brett P. Monia ...