The following is excerpted from the question-and-answer section of the transcript.
(Questions from industry analysts are provided in full, but answers are omitted - download the transcript to see the full question-and-answer session)
Question: Jonathan Chang. - LeeRink Partners - Analyst
: Great. Thanks for taking my questions. First, maybe just to clarify is Dr. Lee available for the Q&A session.
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DECEMBER 11, 2024 / 4:00PM, GMAB.CO - Genmab A/S Virtual R&D Update and ASH Data Review
Question: Jonathan Chang. - LeeRink Partners - Analyst
: Got it. So then maybe for the Genmab team, how are you thinking about potential opportunities for EPCO beyond DLBCL and follicular lymphoma?
What do you need to see before advancing EPCO for CLL in later stage development? And also, what are the considerations for potential autoimmune
disease applications? Thank you.
Question: Yaron Werber - Cowen - Analyst
: Great. Thanks so much for the questions. I have a couple of questions. First of all, when the CLL data is really intriguing, we did a KOL event at ASH
and they're definitely highlighting that as one of the highlights in CLL. When you're looking at the OP T1, you're reducing the CRS nicely, so you
don't have Grade 3 anymore.
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DECEMBER 11, 2024 / 4:00PM, GMAB.CO - Genmab A/S Virtual R&D Update and ASH Data Review
The CR rate was lower, though. It was 10%. Is that just a function of an early follow-up in that specific cohort or anything we should be thinking
about?
And then maybe just secondly, when we looked at the data in -- it was a data for the first-line follicular, the data is really compelling, but there was
a lot of dropouts in that cohort. I think nine patients dropped because of -- because of COVID. Did that sort of happen later on? Or how should we
think about tolerability?Thank you.
Question: Paul Jeng - Guggenheim Securities, LLC - Analyst
: Hey, this is Paul on for Michael Schmidt from Guggenheim. Thanks for taking our question and, and thanks for the helpful call. For Dr. Hutchings,
would be great to get your view on the recent data for talquetamab plus R2 and second line follicular, which showed, I think, around 20 months
PFS. How does that sort of data impact the bar for EPCO and R2? And how do you and your peers plan to sequence -- assume both regimens might
be approved in the setting? Thank you.
Question: Yifeng Liu - HSBC Bank Plc - Analyst
: Thanks for taking my questions and I got acasunlimab. In 2025, there have been a data update for Phase II. Could you maybe share some color on
what to expect in that update? And secondly, on its upcoming Phase III study? And I just wonder if there's any plans to test progression-free survival
in the interim? Thanks.
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DECEMBER 11, 2024 / 4:00PM, GMAB.CO - Genmab A/S Virtual R&D Update and ASH Data Review
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