...Good morning, and welcome to our Agios at ASH 2023 Investor Event. My name is Chris Taylor, Investor Relations for Agios. We're pleased to have so many of you with us both in person and on the webcast. Before we get started, I'd like to remind everyone that some of the statements we make during this event will include forward-looking statements. Actual events and results could differ materially from those expressed and implied as a result of various risks, uncertainties and other factors, including those set forth in our SEC filings. We have an exciting agenda for you this morning. Our CEO, Brian Goff, will provide opening remarks and then turn the microphone to Dr. Sarah Hughes, our Chief Medical Officer and Head of R&D, who will provide highlights of our Joe's presentations at ASH this year. Dr. Omar's 80 Senior Medical Director for our Joe's in the area of sickle cell disease, will review the complete data set for the rise up Phase two study presented on Saturday afternoon. Then Dr....