Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 5 | 5 |
List of Tables | 8 | 1 |
List of Figures | 9 | 1 |
Introduction | 10 | 12 |
Epidemiology | 10 | 1 |
Symptoms | 10 | 1 |
Etiology | 11 | 1 |
Pathophysiology | 11 | 1 |
Co-morbidities and Complications | 12 | 1 |
Classification | 13 | 1 |
Prognosis | 14 | 1 |
Diagnosis | 14 | 2 |
Assessing Treatment Effectiveness | 16 | 1 |
Treatment Algorithm | 16 | 2 |
The Role of Insulin in Type 2 Diabetes | 18 | 1 |
Non-insulin Diabetic Drugs | 19 | 1 |
Biguanides | 19 | 1 |
Glucagon-Like Peptide-1 Agonists and DPP-4 Inhibitors | 19 | 1 |
Sulfonylureas | 20 | 1 |
Sodium-Dependent Glucose Transporter Inhibitors | 20 | 1 |
Thiazolidinediones | 21 | 1 |
Other Drugs | 21 | 1 |
Alpha-Glucosidase (Maltase) Inhibitors | 21 | 1 |
Bile Acid Sequestrants | 21 | 1 |
Key Marketed Products | 22 | 19 |
Metformin | 22 | 1 |
DPP-4 Inhibitors | 23 | 1 |
Januvia (sitagliptin) Merck &Co | 23 | 1 |
Tradjenta (linagliptin) Boehringer Ingelheim | 24 | 1 |
Onglyza (saxagliptin) Bristol-Myers Squibb and AstraZeneca | 25 | 1 |
Nesina (alogliptin) Takeda | 25 | 1 |
Galvus (vildagliptin) Novartis | 26 | 1 |
Tenelia (teneligliptin) Daiichi Sankyo and Mitsubishi Tanabe | 27 | 1 |
GLP-1 Agonists | 28 | 1 |
Byetta and Bydureon (exenatide) Bristol-Myers Squibb | 28 | 1 |
Lyxumia (lixisenatide) Sanofi | 29 | 1 |
Victoza (liraglutide) Novo Nordisk | 30 | 1 |
Sulfonylureas | 31 | 1 |
Glimepiride | 31 | 1 |
Gliclazide | 31 | 1 |
Thiazolidinediones | 32 | 1 |
Actos (pioglitazone) Takeda Pharmaceuticals Limited | 32 | 1 |
Avandia (rosiglitazone) GlaxoSmithKline | 33 | 1 |
Long-Acting Insulins | 34 | 1 |
Lantus (insulin glargine) Sanofi | 34 | 1 |
Levemir (insulin detemir) Novo Nordisk | 35 | 1 |
Tresiba and Ryzodeg (Insulin degludec) Novo Nordisk | 36 | 1 |
SGLT-2 Inhibitors | 37 | 1 |
Forxiga (dapagliflozin) Bristol-Myers Squibb | 37 | 1 |
Invokana (canagliflozin) Janssen | 37 | 1 |
Heat Map for Marketed Products | 38 | 3 |
Pipeline for Type 2 Diabetes | 41 | 23 |
Overall Pipeline | 41 | 1 |
Therapeutic Classes | 42 | 2 |
Rate of Attrition | 44 | 1 |
Failure Rate by Molecule Type | 44 | 1 |
Failure Rate by Therapeutic Class | 45 | 3 |
Reasons for Failure of Developmental Programs | 48 | 1 |
Clinical Trial Duration | 48 | 1 |
Duration by Molecule Type | 48 | 1 |
Duration by Therapeutic Class | 49 | 2 |
Clinical Trial Size | 51 | 1 |
Clinical Trial Size by Molecule Type | 52 | 1 |
Clinical Trial Size by Therapeutic Class | 53 | 2 |
Promising Drugs in the Pipeline | 55 | 1 |
LY-2189265 (dulaglutide) Eli Lilly | 55 | 1 |
Albiglutide GlaxoSmithKline | 55 | 1 |
LC15-044 (gemigliptin) LG Life Sciences | 56 | 1 |
TAK-875 Takeda | 56 | 1 |
Ipragliflozin Astellas Pharma | 57 | 1 |
LX-4211 Lexicon Pharmaceuticals | 57 | 1 |
Imeglimin Poxel SA | 58 | 1 |
CCX-140-B ChemoCentryx | 58 | 1 |
Semaglutide Novo Nordisk A/S | 59 | 1 |
PC-DAC Exendin-4 ConjuChem Biotechnologies | 59 | 1 |
Heat Map for Pipeline Products | 59 | 3 |
Conclusion | 62 | 2 |
Market Forecast to 2019 | 64 | 11 |
Global Market | 64 | 1 |
Treatment Usage Patterns | 64 | 1 |
Market Size | 65 | 1 |
US | 66 | 1 |
Treatment Usage Patterns | 66 | 1 |
Annual Cost of Therapy | 67 | 1 |
Market Size | 67 | 1 |
Top Five Countries of Europe | 68 | 1 |
Treatment Usage Patterns | 68 | 1 |
Annual Cost of Therapy | 69 | 1 |
Market Size | 70 | 2 |
Japan | 72 | 1 |
Treatment Usage Patterns | 72 | 1 |
Annual Cost of Therapy | 72 | 1 |
Market Size | 73 | 1 |
Drivers and Barriers | 73 | 1 |
Drivers | 73 | 1 |
Growing Prevalence of Type 2 Diabetes in Developed Nations | 73 | 1 |
Anticipated Approval of Promising GLP-1 Agonists, SGLT Inhibitors and DPP-4 inhibitors Contribute to Diversity and Fuel Market Growth | 73 | 1 |
Barriers | 74 | 1 |
Widespread Usage of Sulfonylureas and Metformin | 74 | 1 |
High Degree of Competition and Uncertain Overall Treatment Pattern | 74 | 1 |
Deals and Strategic Consolidations | 75 | 14 |
Licensing Deals | 75 | 3 |
TransTech Pharma Enters into Licensing Agreement with Forest Laboratories | 78 | 1 |
Xoma Enters into Licensing Agreement with Les Laboratoires Servier for Xoma 052 | 78 | 1 |
Zealand Pharma Enters into a Licensing and Collaboration Agreement with Boehringer Ingelheim | 78 | 1 |
Exelixis Enters into Licensing Agreement with Bristol-Myers Squibb for XL475 | 79 | 1 |
Prosidion Limited Enters into a Licensing Agreement with Eli Lilly and Company | 79 | 1 |
Metabolex Enters into Licensing Agreement with Sanofi | 79 | 1 |
Wellstat Enters into a License Agreement with Sanofi | 79 | 1 |
CureDM and Lankenau Institute Enter into a Licensing Agreement with Sanofi | 79 | 1 |
Metabolex Enters into a Development and Licensing Agreement with Janssen Pharmaceuticals | 80 | 1 |
Dainippon Sumitomo Pharma Enters into Licensing Agreement with Intercept Pharma for INT-747 | 80 | 1 |
Ipsen Enters into Licensing Agreement with F. Hoffmann-La Roche for BIM 51077 | 80 | 1 |
Glenmark Pharma Enters into Licensing Agreement with Merck KGaA | 80 | 1 |
Euroscreen Enters into Licensing Agreement with Janssen Pharmaceuticals | 81 | 1 |
Phenomix Enters into Licensing Agreement with Chiesi Farmaceutici | 81 | 1 |
Otsuka Pharma Enters into Licensing Agreement with Kyowa Hakko Kirin for Saxagliptin | 81 | 1 |
Nastech Pharma Enters into Licensing Agreement with Amylin Pharma | 81 | 1 |
Emisphere Technologies Enters into a Licensing Agreement with Novo Nordisk | 81 | 1 |
Array BioPharma Enters into a Licensing Agreement with Amgen | 82 | 1 |
Theratechnologies Enters into a Licensing Agreement with OctoPlus | 82 | 1 |
Diabetica Enters into a Licensing Agreement with Amylin | 82 | 1 |
Celtic Therapeutics Enters into a Licensing Agreement with Bellus Health | 82 | 1 |
Aradigm Enters into a Licensing Agreement with Novo Nordisk | 83 | 1 |
Santarus Enters into a License Agreement with Shore Therapeutics | 83 | 1 |
Depomed Enters into a Licensing Agreement with Boehringer Ingelheim | 83 | 1 |
Depomed Enters into a Licensing Agreement with Merck | 83 | 1 |
Depomed Enters into a Licensing Agreement with Teva | 84 | 1 |
Co-development Deals | 84 | 1 |
Eli Lilly Enters into a Co-development Agreement with Boehringer Ingelheim | 85 | 1 |
AstraZeneca Enters into Co-development Agreement with Bristol-Myers Squibb | 86 | 1 |
Metabolex Enters into a Co-development Agreement with Janssen Pharmaceuticals | 86 | 1 |
Amylin Pharma Terminates Co-development Agreement with Eli Lilly for Exenatide | 86 | 1 |
Isis Enters into a Collaboration Agreement with Janssen Pharmaceuticals | 86 | 1 |
Neurocrine Biosciences Enters into a Collaboration Agreement with Boehringer Ingelheim | 87 | 1 |
Intercept Pharma Enters into Co-development Agreement with Servier | 87 | 1 |
Transition Therapeutics Enters into an Agreement with Eli Lilly | 87 | 1 |
Ambrx Enters into a Co-Development Agreement with Bristol-Myers Squibb | 87 | 1 |
Biocompatibles Enters into a Co-Development Agreement with AstraZeneca | 88 | 1 |
Appendix | 89 | 35 |
All Pipeline Drugs by Stage of Development | 89 | 16 |
Discovery | 89 | 2 |
Preclinical and IND-filed | 91 | 4 |
Phase I | 95 | 3 |
Phase II | 98 | 4 |
Phase III and Pre-registration | 102 | 2 |
Undisclosed | 104 | 1 |
Market Forecasts to 2019 | 105 | 4 |
Global | 105 | 1 |
US | 105 | 1 |
UK | 106 | 1 |
France | 106 | 1 |
Germany | 107 | 1 |
Italy | 107 | 1 |
Spain | 108 | 1 |
Japan | 108 | 1 |
Market Definitions | 109 | 1 |
Abbreviations | 109 | 3 |
References for Heat Maps | 112 | 2 |
References | 114 | 5 |
Research Methodology | 119 | 2 |
Coverage | 119 | 1 |
Secondary Research | 120 | 1 |
Primary Research | 120 | 1 |
Therapeutic Landscape | 121 | 1 |
Epidemiology-based Forecasting | 121 | 1 |
Market Size by Geography | 122 | 1 |
Geographical Landscape | 123 | 1 |
Pipeline Analysis | 123 | 1 |
Expert Panel Validation | 123 | 1 |
Contact Us | 123 | 1 |
Disclaimer | 123 | 1 |