Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019 - GBI Research Reports

Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019

Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019 - GBI Research Reports
Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019
Published Oct 18, 2013
123 pages — Published Oct 18, 2013
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About This Report

  
Abstract:

Summary

GBI Research has released its latest report for the pharmaceuticals industry, Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019. There is currently a large number of blood glucose-lowering drugs in the crowded type 2 diabetes market indicated for the treatment of chronically high blood glucose. The market is led by Lantus, which achieved global sales amounting to $6.4 billion in 2012. Over the forecast period from 2012 to 2019, the safer, more efficacious newer classes of drug (GLP-1 agonists, DPP-4 Inhibitors and SGLT-2 inhibitors) are expected to capture substantial market shares, largely replacing older classes such as sulfonylureas and thiazolidinediones. Additionally, a variety of novel drugs belonging to these newer classes are due to enter the market, and are expected to offer a moderate improvement in terms of efficacy and safety. The price of these new therapies is expected to be high, but this is unlikely to hinder their uptake. As a result, as well as an overall increase in the prevalent population, GBI Research believes that the value of the global market has the potential to grow to reach $38.8 billion by 2019.

Scope

- A brief introduction to type 2 diabetes, including the symptoms, pathogenesis, risk factors and diagnosis
- In-depth analysis of major glucose-lowering drugs for type 2 diabetes, including analyses of their safety, efficacy, treatment patterns, strengths/weaknesses and overall commercial prospects. Includes a heat map comparing major drugs in terms of safety, efficacy and dosing parameters.
- Comprehensive review of the pipeline for type 2 diabetes therapies, including individual analysis of a number of late-stage pipeline drugs that are likely to enter the market in the forecast period. The pipeline is analyzed on the basis of phase distribution, molecule types and molecular targets.
- Additional in-depth analysis of pipeline drug clinical trials by phase, molecule type, trial size, trial duration and program failure rate analyses for each molecule type and mechanism of action
- Multi-scenario forecast data for the market up to 2019, taking into account how it will be affected by the introduction of new drugs, the expiry of key patents on current drugs, and changes in disease epidemiology across key developed markets including the US, Japan, Germany, the UK, France, Italy and Spain
- Discussion of the drivers and barriers for market growth

Reasons to buy

- Understand the many different types of type 2 diabetes therapies on the market, from the older, established classes of treatment to newer, moderately superior types of drug, and their positions in the treatment algorithm
- Understand the strengths and weaknesses of each product
- Understand the scope of the pipeline, including which molecule types and mechanisms of action are prominent
- Observe trends in clinical trial duration and size amongst clinical phases and molecule types, and use the clinical trial failure rate analysis to assess the risk profiles of current and/or future developmental programs for type 2 diabetes therapeutics
- Assess the potential clinical and commercial impact of current late-stage pipeline molecules on the type 2 diabetes therapeutics market.

  
Source:
Document ID
GBIHC305MR
Industry
Format:
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Sections

TitleStarting PageNumber of Pages
Table of Contents55
  List of Tables81
  List of Figures91
Introduction1012
  Epidemiology101
  Symptoms101
  Etiology111
  Pathophysiology111
  Co-morbidities and Complications121
  Classification131
  Prognosis141
  Diagnosis142
  Assessing Treatment Effectiveness161
  Treatment Algorithm162
    The Role of Insulin in Type 2 Diabetes181
    Non-insulin Diabetic Drugs191
      Biguanides191
      Glucagon-Like Peptide-1 Agonists and DPP-4 Inhibitors191
      Sulfonylureas201
      Sodium-Dependent Glucose Transporter Inhibitors201
      Thiazolidinediones211
    Other Drugs211
      Alpha-Glucosidase (Maltase) Inhibitors211
      Bile Acid Sequestrants211
Key Marketed Products2219
  Metformin221
  DPP-4 Inhibitors231
    Januvia (sitagliptin) Merck &Co231
    Tradjenta (linagliptin) Boehringer Ingelheim241
    Onglyza (saxagliptin) Bristol-Myers Squibb and AstraZeneca251
    Nesina (alogliptin) Takeda251
    Galvus (vildagliptin) Novartis261
    Tenelia (teneligliptin) Daiichi Sankyo and Mitsubishi Tanabe271
  GLP-1 Agonists281
    Byetta and Bydureon (exenatide) Bristol-Myers Squibb281
    Lyxumia (lixisenatide) Sanofi291
    Victoza (liraglutide) Novo Nordisk301
  Sulfonylureas311
    Glimepiride311
    Gliclazide311
  Thiazolidinediones321
    Actos (pioglitazone) Takeda Pharmaceuticals Limited321
    Avandia (rosiglitazone) GlaxoSmithKline331
  Long-Acting Insulins341
    Lantus (insulin glargine) Sanofi341
    Levemir (insulin detemir) Novo Nordisk351
    Tresiba and Ryzodeg (Insulin degludec) Novo Nordisk361
  SGLT-2 Inhibitors371
    Forxiga (dapagliflozin) Bristol-Myers Squibb371
    Invokana (canagliflozin) Janssen371
  Heat Map for Marketed Products383
Pipeline for Type 2 Diabetes4123
  Overall Pipeline411
  Therapeutic Classes422
  Rate of Attrition441
    Failure Rate by Molecule Type441
    Failure Rate by Therapeutic Class453
  Reasons for Failure of Developmental Programs481
  Clinical Trial Duration481
    Duration by Molecule Type481
    Duration by Therapeutic Class492
  Clinical Trial Size511
    Clinical Trial Size by Molecule Type521
    Clinical Trial Size by Therapeutic Class532
  Promising Drugs in the Pipeline551
    LY-2189265 (dulaglutide) Eli Lilly551
    Albiglutide GlaxoSmithKline551
    LC15-044 (gemigliptin) LG Life Sciences561
    TAK-875 Takeda561
    Ipragliflozin Astellas Pharma571
    LX-4211 Lexicon Pharmaceuticals571
    Imeglimin Poxel SA581
    CCX-140-B ChemoCentryx581
    Semaglutide Novo Nordisk A/S591
    PC-DAC Exendin-4 ConjuChem Biotechnologies591
  Heat Map for Pipeline Products593
  Conclusion622
Market Forecast to 20196411
  Global Market641
    Treatment Usage Patterns641
    Market Size651
  US661
    Treatment Usage Patterns661
    Annual Cost of Therapy671
    Market Size671
  Top Five Countries of Europe681
    Treatment Usage Patterns681
    Annual Cost of Therapy691
    Market Size702
  Japan721
    Treatment Usage Patterns721
    Annual Cost of Therapy721
    Market Size731
  Drivers and Barriers731
    Drivers731
      Growing Prevalence of Type 2 Diabetes in Developed Nations731
      Anticipated Approval of Promising GLP-1 Agonists, SGLT Inhibitors and DPP-4 inhibitors Contribute to Diversity and Fuel Market Growth731
    Barriers741
      Widespread Usage of Sulfonylureas and Metformin741
      High Degree of Competition and Uncertain Overall Treatment Pattern741
Deals and Strategic Consolidations7514
  Licensing Deals753
    TransTech Pharma Enters into Licensing Agreement with Forest Laboratories781
    Xoma Enters into Licensing Agreement with Les Laboratoires Servier for Xoma 052781
    Zealand Pharma Enters into a Licensing and Collaboration Agreement with Boehringer Ingelheim781
    Exelixis Enters into Licensing Agreement with Bristol-Myers Squibb for XL475791
    Prosidion Limited Enters into a Licensing Agreement with Eli Lilly and Company791
    Metabolex Enters into Licensing Agreement with Sanofi791
    Wellstat Enters into a License Agreement with Sanofi791
    CureDM and Lankenau Institute Enter into a Licensing Agreement with Sanofi791
    Metabolex Enters into a Development and Licensing Agreement with Janssen Pharmaceuticals801
    Dainippon Sumitomo Pharma Enters into Licensing Agreement with Intercept Pharma for INT-747801
    Ipsen Enters into Licensing Agreement with F. Hoffmann-La Roche for BIM 51077801
    Glenmark Pharma Enters into Licensing Agreement with Merck KGaA801
    Euroscreen Enters into Licensing Agreement with Janssen Pharmaceuticals811
    Phenomix Enters into Licensing Agreement with Chiesi Farmaceutici811
    Otsuka Pharma Enters into Licensing Agreement with Kyowa Hakko Kirin for Saxagliptin811
    Nastech Pharma Enters into Licensing Agreement with Amylin Pharma811
    Emisphere Technologies Enters into a Licensing Agreement with Novo Nordisk811
    Array BioPharma Enters into a Licensing Agreement with Amgen821
    Theratechnologies Enters into a Licensing Agreement with OctoPlus821
    Diabetica Enters into a Licensing Agreement with Amylin821
    Celtic Therapeutics Enters into a Licensing Agreement with Bellus Health821
    Aradigm Enters into a Licensing Agreement with Novo Nordisk831
    Santarus Enters into a License Agreement with Shore Therapeutics831
    Depomed Enters into a Licensing Agreement with Boehringer Ingelheim831
    Depomed Enters into a Licensing Agreement with Merck831
    Depomed Enters into a Licensing Agreement with Teva841
  Co-development Deals841
    Eli Lilly Enters into a Co-development Agreement with Boehringer Ingelheim851
    AstraZeneca Enters into Co-development Agreement with Bristol-Myers Squibb861
    Metabolex Enters into a Co-development Agreement with Janssen Pharmaceuticals861
    Amylin Pharma Terminates Co-development Agreement with Eli Lilly for Exenatide861
    Isis Enters into a Collaboration Agreement with Janssen Pharmaceuticals861
    Neurocrine Biosciences Enters into a Collaboration Agreement with Boehringer Ingelheim871
    Intercept Pharma Enters into Co-development Agreement with Servier871
    Transition Therapeutics Enters into an Agreement with Eli Lilly871
    Ambrx Enters into a Co-Development Agreement with Bristol-Myers Squibb871
    Biocompatibles Enters into a Co-Development Agreement with AstraZeneca881
Appendix8935
  All Pipeline Drugs by Stage of Development8916
    Discovery892
    Preclinical and IND-filed914
    Phase I953
    Phase II984
    Phase III and Pre-registration1022
    Undisclosed1041
  Market Forecasts to 20191054
    Global1051
    US1051
    UK1061
    France1061
    Germany1071
    Italy1071
    Spain1081
    Japan1081
  Market Definitions1091
  Abbreviations1093
  References for Heat Maps1122
  References1145
  Research Methodology1192
    Coverage1191
    Secondary Research1201
    Primary Research1201
  Therapeutic Landscape1211
  Epidemiology-based Forecasting1211
  Market Size by Geography1221
  Geographical Landscape1231
  Pipeline Analysis1231
  Expert Panel Validation1231
  Contact Us1231
  Disclaimer1231

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Cite this Report

  
MLA:
GBI Research Reports. "Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019" Oct 18, 2013. Alacra Store. May 04, 2025. <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Type-2-Diabetes-Therapeutics-Market-to-2019-A-Shifting-Treatment-Algorithm-and-Intensified-Competition-Expected-to-Drive-Growth-by-2019-2115-608>
  
APA:
GBI Research Reports. (2013). Type 2 Diabetes Therapeutics Market to 2019 - A Shifting Treatment Algorithm and Intensified Competition Expected to Drive Growth by 2019 Oct 18, 2013. New York, NY: Alacra Store. Retrieved May 04, 2025 from <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Type-2-Diabetes-Therapeutics-Market-to-2019-A-Shifting-Treatment-Algorithm-and-Intensified-Competition-Expected-to-Drive-Growth-by-2019-2115-608>
  
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