Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 6 | 5 |
List of Tables | 9 | 1 |
List of Figures | 10 | 1 |
Introduction | 11 | 8 |
Cancer Epidemiology | 11 | 1 |
Disease Initiation and Propagation | 11 | 1 |
Symptoms | 12 | 1 |
Symptoms of Lung Cancer | 12 | 1 |
Symptoms of Prostate Cancer | 12 | 1 |
Symptoms of Colorectal Cancer | 12 | 1 |
Symptoms of Breast Cancer | 12 | 1 |
Symptoms of Melanoma | 12 | 1 |
Symptoms of Stomach Cancer | 12 | 1 |
Current Treatment and Management | 13 | 1 |
Active Surveillance or the Wait-and See Approach | 13 | 1 |
Surgery | 13 | 1 |
Radiation Therapy | 13 | 1 |
Chemotherapy | 13 | 1 |
Targeted Therapy | 13 | 1 |
Hormone Therapy | 14 | 1 |
Immunotherapy | 14 | 1 |
Virally Induced Cancers and Prophylactic Vaccines | 14 | 1 |
Cancer, the Immune system and Therapeutic Vaccines | 15 | 1 |
Mechanisms of Immune System Evasion | 15 | 1 |
Mechanisms of Immune System Disabling | 15 | 1 |
Why Develop Therapeutic Cancer Vaccines? | 16 | 1 |
Types of Therapeutic Cancer Vaccine | 16 | 1 |
Anti-Idiotype Vaccines | 16 | 1 |
Whole-Cell-Derived Vaccines | 16 | 1 |
Cellular Immunotherapy | 17 | 1 |
Antigen-Based Vaccines | 17 | 1 |
DNA-Based Vaccines | 17 | 1 |
Vector-Based (Microorganism-Facilitated) Vaccines | 17 | 1 |
Oncolytic Virus Vaccines | 18 | 1 |
Adjuvants | 18 | 1 |
Marketed Products | 19 | 5 |
Provenge an Autologous Cellular Immunotherapy Vaccine for the Treatment of Hormone-Refractory Prostate Cancer | 19 | 1 |
Overview | 19 | 1 |
Mechanism of Action and Molecular Target | 19 | 1 |
Formulation and Dosing | 19 | 1 |
Provenge within the Clinical Landscape for Prostate Cancer | 19 | 1 |
Company Profile and Patent Expiry | 20 | 1 |
Recent Sales and Commercialization of Provenge | 20 | 2 |
Current and Future Market Competitors for Provenge | 22 | 2 |
Product Pipeline | 24 | 28 |
Pipeline Overview | 24 | 3 |
Developmental Pipeline of all Major Indications | 27 | 1 |
Lung Cancer | 27 | 2 |
Breast Cancer | 29 | 2 |
Colorectal Cancer | 31 | 1 |
Stomach Cancer | 32 | 1 |
Prostate Cancer | 33 | 2 |
Melanoma | 35 | 1 |
Clinical Trials | 36 | 1 |
Clinical Trial Duration | 36 | 2 |
Clinical Trial Size | 38 | 1 |
Clinical Trial Endpoints | 39 | 2 |
Clinical Trial Failure | 41 | 1 |
Clinical Trial Failure Rates | 41 | 1 |
Failure Rates by Vaccine Type | 42 | 1 |
Reasons for Clinical Trial Failure | 43 | 1 |
Key Companies Developing Cancer Vaccines | 44 | 1 |
Promising Drugs in the Developmental Pipeline | 45 | 1 |
Drug: Allovectin | 45 | 1 |
Drug: Lucanix (belagenpumatucel-L) | 46 | 1 |
Drug: BiovaxID | 46 | 1 |
Drug: DCVax L | 47 | 1 |
Drug: DCVax-Prostate | 47 | 1 |
Drug: MAGE-A3 Antigen-Specific Cancer Immunotherapeutic | 48 | 1 |
Drug: GV-1001 | 48 | 1 |
Drug: Hyperacute Pancreas Immunotherapy | 49 | 1 |
Drug: NeuVax (nelipepimut-s) | 49 | 1 |
Drug: OncoVax | 49 | 1 |
Drug: Prostvac (rilimogene galvacirepvec) | 50 | 1 |
Drug: Stimuvax (emepepimut-S) | 50 | 1 |
Drug: OncoVex (talimogene laherparepvec) | 51 | 1 |
Forecasting | 52 | 33 |
Therapeutic Cancer Vaccines Market to 2019 Global | 52 | 1 |
Treatment Usage Patterns | 53 | 1 |
Annual Cost of Treatment | 53 | 1 |
Colorectal Cancer | 53 | 1 |
Emerging Cancer Vaccines and Anticipated Treatment Usage Patterns | 53 | 1 |
Annual Cost of Therapy | 54 | 2 |
Market Size | 56 | 2 |
Glioblastoma Multiforme | 58 | 1 |
Emerging Cancer Vaccines and their Treatment Usage Patterns | 58 | 1 |
Annual Cost of Therapy | 59 | 1 |
Market Size | 60 | 2 |
Lymphoma | 62 | 1 |
Emerging Cancer Vaccines for Lymphoma and their Treatment Usage Patterns | 62 | 1 |
Annual Cost of Therapy | 62 | 2 |
Market Revenues | 64 | 2 |
Melanoma | 66 | 1 |
Emerging Cancer Vaccines and Anticipated Treatment Usage Patterns | 66 | 1 |
Annual Cost of Therapy | 67 | 2 |
Market Size | 69 | 2 |
Non-Small-Cell Lung Cancer | 71 | 1 |
Emerging Vaccines and Treatment Usage Patterns | 71 | 1 |
Annual Cost of Therapy | 71 | 2 |
Market Size | 73 | 1 |
Pancreatic Cancer | 74 | 1 |
Emerging Cancer Vaccines and their Market Impact | 74 | 1 |
Annual Cost of Therapy | 74 | 2 |
Market Revenues | 76 | 2 |
Prostate Cancer | 78 | 1 |
Treatment Usage Patterns and the Impact of Emerging Vaccines | 78 | 1 |
Annual Cost of Treatment | 78 | 2 |
Market Revenues | 80 | 2 |
Drivers and Barriers for Therapeutic Cancer Vaccines Market | 82 | 1 |
Drivers | 82 | 1 |
Patient Desire for Safer and More Effective Treatment | 82 | 1 |
Patient Desire for Extension of Life | 82 | 1 |
High Cost of Treatment Set to Increase | 82 | 1 |
Sustained Innovation in the Developmental Pipeline | 83 | 1 |
Barriers | 83 | 1 |
Issues with Clinical Trial Design | 83 | 1 |
Disease Stage and Patient Selection | 83 | 1 |
Small Companies may Fail to Secure Funding | 83 | 1 |
Manufacturing and Logistics | 83 | 1 |
Pricing and Reimbursement | 84 | 1 |
Appendix | 85 | 31 |
Provenge Clinical Trial Titles (Table 3) | 85 | 1 |
Predicated Annual Cost of Therapy | 85 | 4 |
Colon Cancer | 85 | 1 |
Glioblastoma Multiforme | 85 | 1 |
Lymphoma | 86 | 1 |
Melanoma | 86 | 1 |
Non-Small-Cell Lung Cancer | 87 | 1 |
Pancreatic Cancer | 87 | 1 |
Prostate Cancer | 88 | 1 |
Predicted Market Forecasts | 88 | 4 |
Colon Cancer | 88 | 1 |
Glioblastoma Multiforme | 89 | 1 |
Lymphoma | 89 | 1 |
Melanoma | 90 | 1 |
Non-Small-Cell Lung Cancer | 90 | 1 |
Pancreatic Cancer | 91 | 1 |
Prostate | 91 | 1 |
All Pipeline Drugs by Phase | 92 | 14 |
Discovery | 92 | 1 |
Preclinical | 93 | 2 |
IND-Filed and Phase 0 | 95 | 1 |
Phase I | 96 | 5 |
Phase II | 101 | 4 |
Phase III | 105 | 1 |
Market Definitions | 106 | 1 |
Abbreviations | 107 | 1 |
Sources | 108 | 3 |
Research Methodology | 111 | 3 |
Coverage | 111 | 1 |
Secondary Research | 111 | 1 |
Primary Research | 112 | 1 |
Therapeutic Landscape | 112 | 1 |
Epidemiology-Based Forecasting | 112 | 1 |
Analogous Forecasting Methodology | 113 | 1 |
Diseased Population | 113 | 1 |
Prescription Population | 113 | 1 |
Market Size by Geography | 114 | 1 |
Forecasting Model for Therapeutic Areas | 114 | 1 |
Geographical Landscape | 115 | 1 |
Pipeline Analysis | 115 | 1 |
Expert Panel Validation | 115 | 1 |
Contact Us | 115 | 1 |
Disclaimer | 115 | 1 |