Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 4 | 4 |
List of Tables | 6 | 1 |
List of Figures | 7 | 1 |
Introduction | 8 | 9 |
Overview | 8 | 1 |
Epidemiology | 9 | 1 |
Etiology, Co-morbidities and Risk Factors | 10 | 1 |
Genetics | 10 | 1 |
Psoriatic Arthritis | 10 | 1 |
Mental Health Disorders | 11 | 1 |
Metabolic Syndrome, Smoking, Diet and Alcohol Consumption | 11 | 1 |
Infections | 11 | 1 |
K ebner Phenomenon | 12 | 1 |
Other Immune-mediated Diseases | 12 | 1 |
Pathophysiology | 12 | 1 |
Diagnosis | 13 | 1 |
Treatment Options | 13 | 1 |
Pharmacological Therapies | 14 | 1 |
Non-pharmacological Therapies | 15 | 1 |
Combination and Rotational Therapies | 15 | 1 |
Quality of Life Assessments | 16 | 1 |
Summary | 16 | 1 |
Marketed Products | 17 | 11 |
Overview | 17 | 1 |
Methotrexate-based Products | 17 | 1 |
Sandimmune/Neoral (cyclosporine/modified cyclosporine) Novartis | 18 | 1 |
Soriatane (acitretin) Steifel Laboratories | 19 | 1 |
Fumaderm (dimethyl fumarate and ethyl fumarate) Biogen Idec | 20 | 1 |
Humira (adalimumab) Abbvie Inc. | 21 | 1 |
Enbrel (etanercept) Amgen Inc. | 22 | 1 |
Remicade (infliximab) Janssen Biotech | 23 | 1 |
Stelara (ustekinumab) Janssen Biotech | 24 | 1 |
Marketed Products Heat Map | 25 | 3 |
Pipeline | 28 | 25 |
Overview | 28 | 1 |
Pipeline Size and Distribution by Phase, Molecule Type and Program Type | 29 | 2 |
Pipeline Distribution by Molecular Target | 31 | 2 |
Clinical Trial Landscape | 33 | 1 |
Clinical Trial Duration | 33 | 4 |
Clinical Trial Size | 37 | 4 |
Clinical trial failure rates | 41 | 1 |
Primary and Secondary Endpoints | 42 | 2 |
Summary of Psoriasis Clinical Trials | 44 | 1 |
Promising pipeline molecules | 44 | 1 |
Ixekizumab Eli Lilly | 44 | 1 |
Xeljanz (tofacitinib) Pfizer | 45 | 1 |
Brodalumab Amgen | 46 | 1 |
Apremilast Celgene | 47 | 1 |
Secukinumab Alcon | 48 | 1 |
Heat Map for Pipeline Products | 48 | 5 |
Market Forecast to 2020 | 53 | 15 |
Overview | 53 | 1 |
Global Market | 53 | 3 |
North America | 56 | 1 |
Treatment Usage Patterns | 56 | 1 |
Annual Cost of Treatment | 57 | 2 |
Market Size | 59 | 1 |
Top Five EU Markets | 60 | 1 |
Treatment Usage Patterns | 60 | 1 |
Annual Cost of Treatment | 61 | 1 |
Market Size | 62 | 1 |
Japan | 63 | 1 |
Treatment Usage Patterns | 63 | 1 |
Annual Cost of Treatment | 64 | 1 |
Market Size | 65 | 1 |
Drivers and Barriers for the Systemic Psoriasis Therapeutics Market | 66 | 1 |
Drivers | 66 | 1 |
Rising Global Prevalence | 66 | 1 |
Changes in Patterns of Diagnosis and Treatment | 66 | 1 |
Potential for Innovative Pipeline to Address Significant Unmet Need | 66 | 1 |
High Cost of New Market Entries | 66 | 1 |
Barriers | 66 | 1 |
Use of Phototherapy | 66 | 1 |
Loss of Patent Market Exclusivity for Leading Branded Biologics | 66 | 1 |
Treatment Discontinuation and Limited Treatment Compliance | 67 | 1 |
Co-development and Licensing deals | 68 | 8 |
Co-development Deals | 68 | 3 |
Abbvie Enters into Co-development Agreement with Biotest for Tregalizumab | 71 | 1 |
Lycera Enters into Research Agreement with Merck &Co. | 71 | 1 |
LEO Pharma Enters into Research Agreement with 4SC Discovery for Inflammatory Skin Diseases | 71 | 1 |
Amgen Enters into Co-Development Agreement with AstraZeneca for Five Human Monoclonal Antibodies Including Brodalumab | 71 | 2 |
Licensing Deals | 73 | 2 |
Leo Pharma Enters into Licensing Agreement with Virobay for Psoriasis Drug | 75 | 1 |
Foamix Enters into Licensing Agreement with Dr. Reddy's Labs | 75 | 1 |
Cipher Pharma Enters into Licensing Agreement with IBSA Institut Biochimique for Betesil Patch | 75 | 1 |
Phenex Pharma Enters into Licensing Agreement with Janssen Biotech for Retinoid-Acid Receptor-Related Orphan Receptor Gamma t Program | 75 | 1 |
Appendix | 76 | 26 |
All Pipeline Drugs by Phase | 76 | 12 |
Discovery | 76 | 2 |
Preclinical | 78 | 4 |
Phase I | 82 | 2 |
Phase II | 84 | 2 |
Phase III | 86 | 1 |
Undisclosed | 87 | 1 |
Market Forecasts to 2020 | 87 | 5 |
Major Developed Markets | 87 | 1 |
US | 88 | 1 |
UK | 88 | 1 |
France | 89 | 1 |
Germany | 89 | 1 |
Italy | 90 | 1 |
Spain | 90 | 1 |
Japan | 91 | 1 |
Canada | 91 | 1 |
Abbreviations | 92 | 1 |
References | 93 | 5 |
References for Heat Maps | 98 | 2 |
Marketed Products | 98 | 1 |
Pipeline products | 98 | 2 |
Methodology | 100 | 1 |
Secondary Research | 100 | 1 |
Therapeutic Landscape | 100 | 1 |
Contact Us | 100 | 1 |
Disclaimer | 101 | 1 |