Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 5 | 4 |
List of Tables | 7 | 1 |
List of Figures | 8 | 1 |
Introduction | 9 | 10 |
Pathophysiology and Etiology | 9 | 2 |
Epidemiology | 11 | 2 |
Disease Progression | 13 | 2 |
Treatment | 15 | 4 |
Marketed Products | 19 | 14 |
Hormonal Therapies | 19 | 1 |
Zoladex (Goserelin) AstraZeneca | 19 | 2 |
Lupron Depot (Leuprolide acetate) Abbvie | 21 | 1 |
Triptorelin | 22 | 1 |
Firmagon (degarelix) Ferring | 22 | 1 |
Casodex (Bicalutamide) | 23 | 1 |
Summary | 23 | 1 |
Chemotherapy agents | 24 | 1 |
Taxotere (Docetaxel) Sanofi | 24 | 1 |
Jevtana (Cabazitaxel) Sanofi | 25 | 1 |
Therapeutic Vaccines | 26 | 1 |
Provenge (sipuleucel-T) Dendreon | 26 | 1 |
Targeted therapies (Second Generation Anti-androgens) | 27 | 1 |
Zytiga (Abiraterone acetate) Janssen | 27 | 1 |
Xtandi (Enzalutamide) Astellas/Medivation | 27 | 1 |
Bone Metastasis Treatments | 28 | 1 |
Xofigo (Radium 223) Bayer/Algeta | 28 | 1 |
Xgeva (denosumab) Amgen | 29 | 1 |
Zometa (zoledronic acid) Novartis | 29 | 1 |
Heat Map for Marketed Products | 30 | 3 |
Prostate Cancer Developmental Pipeline | 33 | 14 |
Overall Pipeline | 33 | 2 |
Mechanisms of Action | 35 | 1 |
Clinical Trials | 36 | 1 |
Attrition Rate | 36 | 2 |
Enrollment | 38 | 3 |
Duration | 41 | 2 |
Key Late-Stage Pipeline Molecules | 43 | 1 |
Cometriq (Cabozantinib) Exelixis | 43 | 1 |
OGX-011 (custirsen sodium) Teva | 43 | 1 |
TAK-700 (orteronel) Takeda | 44 | 1 |
ProstAtak (AdvTk+ valcyclovir) Advantagene | 44 | 1 |
ProstVac Bavarian Nordic | 44 | 1 |
Tasquinimod Active Biotech | 45 | 1 |
Yervoy (Ipilimumab) Bristol-Myers Squibb | 46 | 1 |
ARN-509 Aragon Pharmaceuticals, Johnson and Jonhson | 46 | 1 |
Market Forecast to 2019 | 47 | 13 |
Global | 47 | 1 |
Treatment Usage Patterns | 47 | 2 |
Market Size | 49 | 1 |
North America | 50 | 1 |
US | 50 | 1 |
Treatment Usage Patterns | 50 | 1 |
Market Size | 51 | 1 |
Canada | 52 | 1 |
Treatment Usage Patterns | 52 | 1 |
Market Size | 53 | 1 |
Five European Markets | 54 | 1 |
Treatment Usage Patterns | 54 | 2 |
Annual Cost of Therapy | 56 | 1 |
Market Size | 57 | 1 |
Japan | 58 | 1 |
Treatment Usage Patterns | 58 | 1 |
Market Size | 59 | 1 |
Prostate Cancer Therapeutics: Drivers and Barriers | 60 | 2 |
Drivers | 60 | 1 |
Major Unmet Treatment Needs of Late Stage Prostate Cancer Patients | 60 | 1 |
Increasing Disease Population | 60 | 1 |
New Drugs Entering the Market | 60 | 1 |
Rapid and Robust Uptake of Recently Approved High-Cost Therapies | 60 | 1 |
Rapid Inflation Rate for Specialty Pharmaceutical Products in the US | 60 | 1 |
Market Capture of Previously Untreated Patient Segments | 61 | 1 |
Barriers | 61 | 1 |
Uncertain Treatment Algorithm | 61 | 1 |
Uptake Limited by High Prices for New Products | 61 | 1 |
Patent Expiry of Taxotere | 61 | 1 |
Intensifying Competition Acting as a Barrier to Market Capture | 61 | 1 |
Licensing and Co-development Deals Analysis | 62 | 8 |
Licensing Deals | 62 | 3 |
Algeta Enters into Licensing Agreement with Bayer Schering for Xofigo | 65 | 1 |
Sanofi-Aventis Enters into a Licensing Agreement with Oxford BioMedica | 65 | 1 |
Novacea Enters Into Licensing Agreement With Schering-Plough For Asentar | 65 | 1 |
Teva Pharma Enters into a Licensing Agreement with Oncogenex Pharma for OGX-011 | 65 | 1 |
Hoffman La Roche Enters into a Licensing Agreement with Inovio Pharmaceuticals for Prostate Cancer and Hepatitis B Immunotherapy Products | 66 | 1 |
Colby Pharmaceutical Company Enters into a Licensing Agreement with MannKind for Cancer Immunotherapy Products | 66 | 1 |
Ipsen Enters into a Licensing Agreement with GTx | 66 | 1 |
Protox Therapeutics Enters into a Licensing Agreement with Kissei Pharma | 67 | 1 |
AEterna Zentaris Enters Into License And Collaboration Agreement With Nippon Kayaku For Ozarelix | 67 | 1 |
Orion Corporation Enters Into Agreement With Indevus Pharmaceuticals | 67 | 1 |
Co-Development Deals | 68 | 1 |
Medivation Enters into Co-Development Agreement with Astellas Pharma | 69 | 1 |
Takeda Pharma Enters into an Agreement with Cell Genesys | 69 | 1 |
Active Biotech Enters into Co-Development Agreement with Ipsen | 69 | 1 |
Appendix | 70 | 38 |
Market Definitions | 70 | 1 |
Abbreviations | 70 | 3 |
Sources | 73 | 5 |
Sources for Marketed Products Heat Map | 78 | 1 |
Scientific Support | 78 | 1 |
Research Methodology | 78 | 5 |
Coverage | 79 | 1 |
Secondary Research | 79 | 1 |
Therapeutic Landscape | 79 | 1 |
Epidemiology-Based Forecasting | 80 | 1 |
Market Size by Geography | 81 | 1 |
Geographical Landscape | 82 | 1 |
Pipeline Analysis | 82 | 1 |
Competitive Landscape | 82 | 1 |
Expert Panel Validation | 82 | 1 |
All Publicly Announced Pipeline Products, by Phase | 83 | 21 |
Discovery | 83 | 2 |
Preclinical/IND-Filed | 85 | 9 |
Phase I | 94 | 3 |
Phase II | 97 | 4 |
Phase III/Pre-Registration | 101 | 2 |
Undisclosed Stage of Development | 103 | 1 |
Tabular Forecast Data | 103 | 5 |
Global | 103 | 1 |
US | 104 | 1 |
UK | 104 | 1 |
France | 105 | 1 |
Germany | 105 | 1 |
Italy | 106 | 1 |
Spain | 106 | 1 |
Japan | 107 | 1 |
Canada | 107 | 1 |
Disclaimer | 107 | 1 |