Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management - GBI Research Reports

Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management

Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management - GBI Research Reports
Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management
Published May 18, 2012
91 pages — Published May 18, 2012
Price US$ 3,500.00  |  Buy this Report Now

About This Report

  
Abstract:

Summary

GBI Research, the leading business intelligence provider, has released its latest research, Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management, provides in-depth analysis of unmet needs, drivers and barriers that impact the opioids market. The report analyzes current method of practice for various indications including post-operative pain management, osteoarthritis, cancer pain, neuropathic pain and lower back pain. Treatment flow, prescription share, driver and restraints have been analyzed with respect to individual market. Trends followed in opioid abuse and regulations and various strategies applied to control are further analyzed into the report. Furthermore, the report provides competitive benchmarking for the leading products and analyzes the pipeline portfolio that shapes the global prescribing trends in opioids.

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GBI Researchs team of industry experts.

Pain is a widespread problem across the world. More than 25% of the total population suffers from some clinically significant pain in a year. Since pain considerably affects day to day life, its management presents a considerable challenge for physicians. Inadequate pain control remains a major problem across the world. There is an urgent and unmet need to manage these pain related problems accurately. Currently, management of pain is not efficient due to the low rates of treatment seeking and diagnosis. In many cases such as cancer pain, the pain is under-treated in more than half of the cases that take treatment. This is primarily due to the absence of a perfect pain management solution. Pain management can be most effective only when the underlying disease conditions are cured. However, the indications studied as part of this report do not offer any effective cure. The combination of under managed pain, low awareness, and fear of addiction to some classes of pain medications is preventing people suffering pain from seeking treatment 100% of the time.

The market for pain management therapeutics is comprised of therapies such as opioids, non-steroidal anti-inflammatory drugs (NSAIDs), local anesthetics, tricyclic antidepressants and anticonvulsants. Many efficacious pain therapies are associated with several unwanted side effects. Opioids, the largest pain therapy class, cause a number of side effects, such as nausea, vomiting, constipation and somnolence, and can cause severe respiratory depression. NSAIDs can cause gastrointestinal (GI) upset, increase cardiovascular risks, and cause kidney and liver damage.

GBI Research indicates that the pain market is growing with huge potentials, despite of patent expiries and generic substitution. Rapid growth of elderly population worldwide and an escalation in the prevalence of painful conditions such as cancer and arthritis have boosted the use of opioids and pain management drugs. Despite concerns about diversion, misuse and abuse and addiction, the opioid market continues to grow with its increased use by physicians in the treatment of pain, in turn driving the market for pain management drugs.

Scope

- Analysis of various prescribing tends for pain management and key associated factors with opioids prescription.
- Influencers, alternatives, formulations and different modes for opioid delivery have been analyzed.
- The report further analyzes related regulations and different perspectives of Opioid prescription.
- Analysis of the major prescribing sectors, including post-operative pain, osteoarthritis, cancer pain, neuropathic pain and low back pain.
- Major marketed products in the opioids market are enlisted providing th

  
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Document ID
GBIHC179MR
Industry
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Sections

TitleStarting PageNumber of Pages
Table of Contents55
  List of Tables91
  List of Figures91
Introduction101
Prescribing Trends in Opioids - Introduction to Opioids116
  World Health Organization Pain Ladder112
  Opioids in Pain Management131
    Opioids Remain the Mainstay of Chronic Pain Treatment131
    Opioids Classification132
    Leading Opioids in the Market151
      Branded Generics Play a Major Role151
      Novel Drug Delivery Techniques Push Opioid Usage161
    Adverse Effects Associated with Opioids Restrain its Prescription161
Prescribing Trends in Opioids - Overview1725
  Factors in Opioid Prescription191
    Alternatives to Opioid Use201
    Advantages and Disadvantages of Opioids over the Alternatives201
      Opioid Analgesics203
      Non Opioid Analgesics231
  Formulations and Mode of Delivery for Opioids241
    Route of Administration241
      Oral Route241
      Sublingual and Buccal Route241
      Transdermal Route241
      Transmucosal241
      Aerosol241
      Intravenous Route251
      Intramuscular Route251
      Subcutaneous Route251
      Duration of Opioid Treatment251
    Drug Dosing251
    Patients Compliance261
  Trends in Opioids Prescription271
    Gold Standards for Opioid Prescription271
  Acute and Chronic Pain281
    Use of Opioid Medications for Acute Pain281
      Treatment of Acute Pain281
      Contraindications and Relative Contraindications291
    Use of Opioid Medications for Chronic Pain301
      Patient Assessment for Pain Management301
  Definition of Low, Moderate and Severe Pain311
  Regulations and Opioids Prescription311
    Impact of REMS on Opioids Prescription321
      What is REMS?322
      Implications of REMS341
      REMS for Opioids351
      Implications for Patients and Physicians361
    FDA Regulations Regarding Opioids371
      FDA Releases New REMS Proposal for Opioid Prescription Oversight371
      FDA Regulations on Opioid Combinations with Acetaminophen381
      Darvocet, Darvon (propoxyphene) Withdrawn from the Market381
    Risk Evaluation and Mitigation Strategy381
    Physicians Perspective of REMS381
      What is in REMS?391
    Differentiating physical dependence, tolerance and addiction401
    Future treatments and abuse deterrent formulations401
      FDA Rejects New Formulation411
Prescribing Trends in Opioids - Post-operative Pain426
  Current Practice422
    Treatment Flow441
    Patients Indicated for Opioid Use441
      Prescription Share of Opioids in Moderate and Severe Post-operative Pain Patients451
  Prescription Trends461
    Post-operative Nausea and Vomiting461
  Drivers and Restraints for the Opioids Market for Post-operative Pain461
    Drivers for Prescribing Trends in Post-operative Pain471
      Substantial Unmet Need Increases Market Potential471
      Titration of Opioids is Convenient in a Surgical Facility471
    Restraints for Prescribing Trends in Post-operative Pain471
      Expansion of Minimally Invasive Surgical Procedures471
      Perioperative Side Effects471
Prescribing Trends in Opioids - Osteoarthritis Pain485
  Current Practice481
    Treatment Flow491
    Patients Indicated for Opioid Use501
      Share of Opioids in Moderate and Severe Osteoarthritis Pain Patients501
  Drivers and Restraints for the Opioids Market for Osteoarthritis Pain511
    Drivers for Prescribing Trends in Osteoarthritis Pain521
      Aging Population521
      Rapid Increase of the Obesity Population521
      Lifestyle Changes Increase Incidence of Osteoarthritis521
    Restraints for Prescribing Trends in Osteoarthritis Pain521
      Opioids Associated with Several Side Effects521
Prescribing Trends in Opioids - Cancer Pain535
  Current Practice531
    Treatment Flow541
    Patients Indicated for Opioid Use551
      Share of Opioids in Moderate and Severe Cancer Pain Patients551
  Drivers and Restraints for the Opioids Market for Cancer Pain561
    Drivers for Prescribing Trends in Cancer Pain561
      Rising Incidence of Cancer Drives the Market561
      New Modes of Delivery Improve Pain Management for a Longer Duration561
    Restraints for Prescribing Trends in Cancer Pain571
      Concerns over the Risks of Addiction Related to Drug Therapy Affect the Prescription Rate571
      Patient Fears that Pain Treatment will Interfere with Cancer Treatment571
Prescribing Trends in Opioids - Neuropathic Pain585
  Current Practice581
    Treatment Flow591
    Patients Indicated for Opioid Use601
      Share of Opioids in Moderate and Severe Neuropathic Pain Patients601
  Drivers and Restraints for the Opioids Market for Neuropathic Pain611
    Drivers for Prescribing Trends in Neuropathic Pain611
      Aging Population and Increasing Prevalence of Diabetes and HIV611
      Increasing Treatment Seeking Behavior will Drive the Patient Volumes611
    Restraints for Prescribing Trends in Neuropathic Pain611
      Absence of Accurate Diagnostic Tools for Pain Detection Act as a Hindrance for Market Growth611
      Neuropathic Pain is Generally Common and does not Respond to Opioids621
Prescribing Trends in Opioids - Low Back Pain634
  Current Practice631
    Treatment Flow631
    Patients Indicated for Opioid Use641
      Share of Opioids in Moderate and Severe Low Back Pain Patients641
  Drivers and Restraints for the Opioid Market for Low Back Pain651
    Drivers for Prescribing Trends in Low Back Pain651
      Rising Elderly Population will Drive the Market651
      Sedentary Lifestyle Increases Low Back Pain651
    Restraints for Prescribing Trends in Low Back Pain661
      Low Treatment Seeking Rate and Low Prescription Rate Restricts the Market661
Prescribing Trends in Opioids - Opioid Abuse675
  Opioid Dependence671
  Opioid Abuse681
    Patient/Abuser681
    Diversion of Opioid Prescriptions681
  Regulations to Reduce the Abuse of Opioids691
    REMS strategies691
      Labeling691
      Urine Toxicological Screens for Opioids691
  Abuse Deterrent Formulations701
    Embeda701
    Remoxy701
    Oxecta711
Prescribing Trends in Opioids - Major Drugs7211
  Duragesic (fentanyl)721
    Mechanism of Action721
    Product Description:721
    Safety Issues721
  Ultram ER (tramadol hydrochloride)731
    Mechanism of Action731
    Product Description731
    Safety Issues731
    Efficacy Details731
  Pavinal-Atropine (oxycodone hydrochloride hydrate + hydrocotarnine hydrochloride + atropine sulfate)741
    Mechanism of Action741
    Product Description:741
    Safety Issues741
  OxyContin (oxycodone hydrochloride)751
    Mechanism of Action751
    Product Description751
    Safety Issues751
    Efficacy Details751
  Vicodin (hydrocodone bitartrate + acetaminophen)761
    Mechanism of Action761
    Product Description761
    Safety Issues761
  Buprelor (buprenorphine)761
    Mechanism of Action761
    Product Description761
    Safety Issues771
  Dividol (viminolo parahydroxybenzoate)771
    Mechanism of Action771
    Product Description:771
    Safety Issues771
  Filnarine SR (morphine sulfate pentahydrate)781
    Mechanism of Action781
    Product Description781
    Safety Issues781
  Nalbuphine (nalbuphine hydrochloride)781
    Mechanism of Action781
    Product Description781
    Safety Issues791
  Spasmoplus (propyphenazone)791
    Mechanism of Action791
    Product Description791
    Safety Issues791
  Mypaid (dihydrocodeine)791
    Mechanism of Action791
    Product Description791
    Safety Issues801
  Yantil (tapentadol hydrochloride)801
    Mechanism of Action801
    Product Description801
    Safety Issues801
  Nucynta (tapentadol hydrochloride)811
    Mechanism of Action811
    Product Description811
    Safety Issues811
    Efficacy Details821
Prescribing Trends in Opioids - Pipeline Analysis835
  Introduction831
  Profiles of Key Late-Stage Drugs in the Opioids Market841
    Fentanyl Taifun - AKELA Pharma Inc.841
      Mechanism of Action841
    Fentanyl Sublingual Spray - Insys Therapeutics, Inc.851
    Oxycodone Hydrochloride - Mundipharma International Limited851
      Mechanism of Action851
    CEP-33237 Teva Pharmaceuticals (Cephalon, Inc.)851
    ELI-216 - Elite Pharmaceuticals, Inc.851
      Mechanism of Action861
    ALO-02 (Oxycodone-naltrexone)861
      Mechanism of Action861
  Price Premium on New Dose Forms871
  Price Premium on Abuse Deterrent Formulations in the Pipeline871
Prescribing Trends in Opioids - Appendix884
  Market Definitions881
  Abbreviations881
  Sources881
  Research Methodology892
    Coverage891
    Secondary Research901
    Primary Research901
  Pipeline Analysis902
    Expert Panel Validation911
  Contact Us911
  Disclaimer911

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Cite this Report

  
MLA:
GBI Research Reports. "Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management" May 18, 2012. Alacra Store. May 07, 2025. <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Prescribing-Trends-in-Opioids-Driven-by-Efficacy-Advantages-Opioids-to-Remain-the-Mainstay-of-Breakthrough-Pain-Management-2115-415>
  
APA:
GBI Research Reports. (2012). Prescribing Trends in Opioids - Driven by Efficacy Advantages, Opioids to Remain the Mainstay of Breakthrough Pain Management May 18, 2012. New York, NY: Alacra Store. Retrieved May 07, 2025 from <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Prescribing-Trends-in-Opioids-Driven-by-Efficacy-Advantages-Opioids-to-Remain-the-Mainstay-of-Breakthrough-Pain-Management-2115-415>
  
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