Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 5 | 5 |
List of Tables | 9 | 1 |
List of Figures | 9 | 1 |
Introduction | 10 | 1 |
Prescribing Trends in Opioids - Introduction to Opioids | 11 | 6 |
World Health Organization Pain Ladder | 11 | 2 |
Opioids in Pain Management | 13 | 1 |
Opioids Remain the Mainstay of Chronic Pain Treatment | 13 | 1 |
Opioids Classification | 13 | 2 |
Leading Opioids in the Market | 15 | 1 |
Branded Generics Play a Major Role | 15 | 1 |
Novel Drug Delivery Techniques Push Opioid Usage | 16 | 1 |
Adverse Effects Associated with Opioids Restrain its Prescription | 16 | 1 |
Prescribing Trends in Opioids - Overview | 17 | 25 |
Factors in Opioid Prescription | 19 | 1 |
Alternatives to Opioid Use | 20 | 1 |
Advantages and Disadvantages of Opioids over the Alternatives | 20 | 1 |
Opioid Analgesics | 20 | 3 |
Non Opioid Analgesics | 23 | 1 |
Formulations and Mode of Delivery for Opioids | 24 | 1 |
Route of Administration | 24 | 1 |
Oral Route | 24 | 1 |
Sublingual and Buccal Route | 24 | 1 |
Transdermal Route | 24 | 1 |
Transmucosal | 24 | 1 |
Aerosol | 24 | 1 |
Intravenous Route | 25 | 1 |
Intramuscular Route | 25 | 1 |
Subcutaneous Route | 25 | 1 |
Duration of Opioid Treatment | 25 | 1 |
Drug Dosing | 25 | 1 |
Patients Compliance | 26 | 1 |
Trends in Opioids Prescription | 27 | 1 |
Gold Standards for Opioid Prescription | 27 | 1 |
Acute and Chronic Pain | 28 | 1 |
Use of Opioid Medications for Acute Pain | 28 | 1 |
Treatment of Acute Pain | 28 | 1 |
Contraindications and Relative Contraindications | 29 | 1 |
Use of Opioid Medications for Chronic Pain | 30 | 1 |
Patient Assessment for Pain Management | 30 | 1 |
Definition of Low, Moderate and Severe Pain | 31 | 1 |
Regulations and Opioids Prescription | 31 | 1 |
Impact of REMS on Opioids Prescription | 32 | 1 |
What is REMS? | 32 | 2 |
Implications of REMS | 34 | 1 |
REMS for Opioids | 35 | 1 |
Implications for Patients and Physicians | 36 | 1 |
FDA Regulations Regarding Opioids | 37 | 1 |
FDA Releases New REMS Proposal for Opioid Prescription Oversight | 37 | 1 |
FDA Regulations on Opioid Combinations with Acetaminophen | 38 | 1 |
Darvocet, Darvon (propoxyphene) Withdrawn from the Market | 38 | 1 |
Risk Evaluation and Mitigation Strategy | 38 | 1 |
Physicians Perspective of REMS | 38 | 1 |
What is in REMS? | 39 | 1 |
Differentiating physical dependence, tolerance and addiction | 40 | 1 |
Future treatments and abuse deterrent formulations | 40 | 1 |
FDA Rejects New Formulation | 41 | 1 |
Prescribing Trends in Opioids - Post-operative Pain | 42 | 6 |
Current Practice | 42 | 2 |
Treatment Flow | 44 | 1 |
Patients Indicated for Opioid Use | 44 | 1 |
Prescription Share of Opioids in Moderate and Severe Post-operative Pain Patients | 45 | 1 |
Prescription Trends | 46 | 1 |
Post-operative Nausea and Vomiting | 46 | 1 |
Drivers and Restraints for the Opioids Market for Post-operative Pain | 46 | 1 |
Drivers for Prescribing Trends in Post-operative Pain | 47 | 1 |
Substantial Unmet Need Increases Market Potential | 47 | 1 |
Titration of Opioids is Convenient in a Surgical Facility | 47 | 1 |
Restraints for Prescribing Trends in Post-operative Pain | 47 | 1 |
Expansion of Minimally Invasive Surgical Procedures | 47 | 1 |
Perioperative Side Effects | 47 | 1 |
Prescribing Trends in Opioids - Osteoarthritis Pain | 48 | 5 |
Current Practice | 48 | 1 |
Treatment Flow | 49 | 1 |
Patients Indicated for Opioid Use | 50 | 1 |
Share of Opioids in Moderate and Severe Osteoarthritis Pain Patients | 50 | 1 |
Drivers and Restraints for the Opioids Market for Osteoarthritis Pain | 51 | 1 |
Drivers for Prescribing Trends in Osteoarthritis Pain | 52 | 1 |
Aging Population | 52 | 1 |
Rapid Increase of the Obesity Population | 52 | 1 |
Lifestyle Changes Increase Incidence of Osteoarthritis | 52 | 1 |
Restraints for Prescribing Trends in Osteoarthritis Pain | 52 | 1 |
Opioids Associated with Several Side Effects | 52 | 1 |
Prescribing Trends in Opioids - Cancer Pain | 53 | 5 |
Current Practice | 53 | 1 |
Treatment Flow | 54 | 1 |
Patients Indicated for Opioid Use | 55 | 1 |
Share of Opioids in Moderate and Severe Cancer Pain Patients | 55 | 1 |
Drivers and Restraints for the Opioids Market for Cancer Pain | 56 | 1 |
Drivers for Prescribing Trends in Cancer Pain | 56 | 1 |
Rising Incidence of Cancer Drives the Market | 56 | 1 |
New Modes of Delivery Improve Pain Management for a Longer Duration | 56 | 1 |
Restraints for Prescribing Trends in Cancer Pain | 57 | 1 |
Concerns over the Risks of Addiction Related to Drug Therapy Affect the Prescription Rate | 57 | 1 |
Patient Fears that Pain Treatment will Interfere with Cancer Treatment | 57 | 1 |
Prescribing Trends in Opioids - Neuropathic Pain | 58 | 5 |
Current Practice | 58 | 1 |
Treatment Flow | 59 | 1 |
Patients Indicated for Opioid Use | 60 | 1 |
Share of Opioids in Moderate and Severe Neuropathic Pain Patients | 60 | 1 |
Drivers and Restraints for the Opioids Market for Neuropathic Pain | 61 | 1 |
Drivers for Prescribing Trends in Neuropathic Pain | 61 | 1 |
Aging Population and Increasing Prevalence of Diabetes and HIV | 61 | 1 |
Increasing Treatment Seeking Behavior will Drive the Patient Volumes | 61 | 1 |
Restraints for Prescribing Trends in Neuropathic Pain | 61 | 1 |
Absence of Accurate Diagnostic Tools for Pain Detection Act as a Hindrance for Market Growth | 61 | 1 |
Neuropathic Pain is Generally Common and does not Respond to Opioids | 62 | 1 |
Prescribing Trends in Opioids - Low Back Pain | 63 | 4 |
Current Practice | 63 | 1 |
Treatment Flow | 63 | 1 |
Patients Indicated for Opioid Use | 64 | 1 |
Share of Opioids in Moderate and Severe Low Back Pain Patients | 64 | 1 |
Drivers and Restraints for the Opioid Market for Low Back Pain | 65 | 1 |
Drivers for Prescribing Trends in Low Back Pain | 65 | 1 |
Rising Elderly Population will Drive the Market | 65 | 1 |
Sedentary Lifestyle Increases Low Back Pain | 65 | 1 |
Restraints for Prescribing Trends in Low Back Pain | 66 | 1 |
Low Treatment Seeking Rate and Low Prescription Rate Restricts the Market | 66 | 1 |
Prescribing Trends in Opioids - Opioid Abuse | 67 | 5 |
Opioid Dependence | 67 | 1 |
Opioid Abuse | 68 | 1 |
Patient/Abuser | 68 | 1 |
Diversion of Opioid Prescriptions | 68 | 1 |
Regulations to Reduce the Abuse of Opioids | 69 | 1 |
REMS strategies | 69 | 1 |
Labeling | 69 | 1 |
Urine Toxicological Screens for Opioids | 69 | 1 |
Abuse Deterrent Formulations | 70 | 1 |
Embeda | 70 | 1 |
Remoxy | 70 | 1 |
Oxecta | 71 | 1 |
Prescribing Trends in Opioids - Major Drugs | 72 | 11 |
Duragesic (fentanyl) | 72 | 1 |
Mechanism of Action | 72 | 1 |
Product Description: | 72 | 1 |
Safety Issues | 72 | 1 |
Ultram ER (tramadol hydrochloride) | 73 | 1 |
Mechanism of Action | 73 | 1 |
Product Description | 73 | 1 |
Safety Issues | 73 | 1 |
Efficacy Details | 73 | 1 |
Pavinal-Atropine (oxycodone hydrochloride hydrate + hydrocotarnine hydrochloride + atropine sulfate) | 74 | 1 |
Mechanism of Action | 74 | 1 |
Product Description: | 74 | 1 |
Safety Issues | 74 | 1 |
OxyContin (oxycodone hydrochloride) | 75 | 1 |
Mechanism of Action | 75 | 1 |
Product Description | 75 | 1 |
Safety Issues | 75 | 1 |
Efficacy Details | 75 | 1 |
Vicodin (hydrocodone bitartrate + acetaminophen) | 76 | 1 |
Mechanism of Action | 76 | 1 |
Product Description | 76 | 1 |
Safety Issues | 76 | 1 |
Buprelor (buprenorphine) | 76 | 1 |
Mechanism of Action | 76 | 1 |
Product Description | 76 | 1 |
Safety Issues | 77 | 1 |
Dividol (viminolo parahydroxybenzoate) | 77 | 1 |
Mechanism of Action | 77 | 1 |
Product Description: | 77 | 1 |
Safety Issues | 77 | 1 |
Filnarine SR (morphine sulfate pentahydrate) | 78 | 1 |
Mechanism of Action | 78 | 1 |
Product Description | 78 | 1 |
Safety Issues | 78 | 1 |
Nalbuphine (nalbuphine hydrochloride) | 78 | 1 |
Mechanism of Action | 78 | 1 |
Product Description | 78 | 1 |
Safety Issues | 79 | 1 |
Spasmoplus (propyphenazone) | 79 | 1 |
Mechanism of Action | 79 | 1 |
Product Description | 79 | 1 |
Safety Issues | 79 | 1 |
Mypaid (dihydrocodeine) | 79 | 1 |
Mechanism of Action | 79 | 1 |
Product Description | 79 | 1 |
Safety Issues | 80 | 1 |
Yantil (tapentadol hydrochloride) | 80 | 1 |
Mechanism of Action | 80 | 1 |
Product Description | 80 | 1 |
Safety Issues | 80 | 1 |
Nucynta (tapentadol hydrochloride) | 81 | 1 |
Mechanism of Action | 81 | 1 |
Product Description | 81 | 1 |
Safety Issues | 81 | 1 |
Efficacy Details | 82 | 1 |
Prescribing Trends in Opioids - Pipeline Analysis | 83 | 5 |
Introduction | 83 | 1 |
Profiles of Key Late-Stage Drugs in the Opioids Market | 84 | 1 |
Fentanyl Taifun - AKELA Pharma Inc. | 84 | 1 |
Mechanism of Action | 84 | 1 |
Fentanyl Sublingual Spray - Insys Therapeutics, Inc. | 85 | 1 |
Oxycodone Hydrochloride - Mundipharma International Limited | 85 | 1 |
Mechanism of Action | 85 | 1 |
CEP-33237 Teva Pharmaceuticals (Cephalon, Inc.) | 85 | 1 |
ELI-216 - Elite Pharmaceuticals, Inc. | 85 | 1 |
Mechanism of Action | 86 | 1 |
ALO-02 (Oxycodone-naltrexone) | 86 | 1 |
Mechanism of Action | 86 | 1 |
Price Premium on New Dose Forms | 87 | 1 |
Price Premium on Abuse Deterrent Formulations in the Pipeline | 87 | 1 |
Prescribing Trends in Opioids - Appendix | 88 | 4 |
Market Definitions | 88 | 1 |
Abbreviations | 88 | 1 |
Sources | 88 | 1 |
Research Methodology | 89 | 2 |
Coverage | 89 | 1 |
Secondary Research | 90 | 1 |
Primary Research | 90 | 1 |
Pipeline Analysis | 90 | 2 |
Expert Panel Validation | 91 | 1 |
Contact Us | 91 | 1 |
Disclaimer | 91 | 1 |