Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies - GBI Research Reports

Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies

Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies - GBI Research Reports
Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies
Published Jul 04, 2016
131 pages — Published Jul 04, 2016
Price US$ 4,995.00  |  Buy this Report Now

About This Report

  
Abstract:

Summary

Osteoporosis, the most common metabolic bone disease, is characterized by low bone mass, microarchitectural deterioration of bone tissue, and a consequent increase in fracture risk. Osteoporosis is generally known as an asymptomatic disease, as there are no visible signs until a fracture occur. In most of the cases, fracture is the clinical outcome associated with osteoporosis, and it has a complex pathogenesis that involves trauma to the bone and increased skeletal fragility. Osteoporosis is a major global public health problem, associated with significant morbidity, mortality, and socioeconomic burden. An aging global population will result in an increased number of people living with the condition, thereby acting as a driver for revenue growth.

The osteoporosis market is undergoing a gradual transition from a focus on antiresorptive therapies to anabolic drug treatment. The market is set to be driven by recently launched products, and the approval of drugs that will supplement current market leaders and offer greater therapeutic options. The marketed products landscape comprises a wide range of treatment options, including bisphosphonates, SERMs, RANKL inhibitors, a dual-action non-bisphosphonate (strontium ranelate), calcitonins and PTH analogues. Nevertheless, significant unmet need remains for products that can improve bone formation, as well as effective antiresorptive therapies that offer increased compliance with few side effects.

Scope

The osteoporosis Asia-Pacific market will be valued at $7.7 billion in 2022, growing from $4.5 billion in 2015 at a CAGR of 7.8%.
- Bisphosphonates and SERMs dominate the osteoporosis market. However, unmet needs exist in terms of safety and efficacy. Will the drugs under development fulfill the unmet needs of the osteoporosis market?
- How will immunotherapies such as Prolia contribute to growth?
- What effect will the patent expirations of currently branded therapies have on market value?
The pipeline contains a range of molecule types and molecular targets, including those that are well established in osteoporosis, and novel, first-in-class therapies.
- Which molecular targets appear most frequently in the pipeline?
- Is there strong potential for the pipeline to address unmet needs within the osteoporosis market?
- Will the pipeline address unmet needs related to limited anabolic therapies for osteoporosis patients?
The market forecasts indicate that Japan will contribute the most to the Asia-Pacific market value, due to the emergence of novel therapies.
- How will the annual cost of therapy and market size vary between the five Asia-Pacific markets?
- How could changes in risk factors such as aging population, calcium and vitamin D deficiency influence the market?
Various drivers and barriers will influence the market over the forecast period.
- What are the barriers that limit the uptake of premium-priced therapeutics in the assessed countries?
- Which factors are most likely to drive the market in these countries?

Reasons to buy

This report will allow you to -
- Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis, including a clinical comparison of marketed therapies.
- Visualize the composition of the osteoporosis market in terms of dominant therapies, with their clinical and commercial standing. Unmet needs are highlighted to allow a competitive understanding of gaps in the current market.
- Analyze the osteoporosis pipeline and stratify pipeline therapies by stage of development, molecule type and molecular target.
- Understand the potential

  
Source:
Document ID
GBIHC410MR
Industry
Format:
PDF Adobe Acrobat
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Sections

TitleStarting PageNumber of Pages
1 Table of Contents55
  1.1 List of Tables81
  1.2 List of Figures82
2 Introduction1016
  2.1 Disease Introduction111
  2.2 Epidemiology111
  2.3 Symptoms122
  2.4 Etiology and Pathophysiology141
    2.4.1 Pathophysiology141
  2.5 Diagnosis152
  2.6 Disease Stages173
  2.7 Prognosis201
  2.8 Treatment Options211
    2.8.1 Treatment Algorithm211
    2.8.2 Pharmacological Treatments221
      2.8.2.1 Bisphosphonates231
      2.8.2.2 Dual-Action Non-Bisphosphonates231
      2.8.2.3 Selective Estrogen Receptor Modulators231
      2.8.2.4 Receptor Activator of Nuclear Factor Kappa-B Ligand Inhibitor231
      2.8.2.5 Parathyroid Hormone241
      2.8.2.6 Calcitonins241
    2.8.3 Non-Pharmacological Treatments241
    2.8.4 Exercise241
    2.8.5 Dietary Interventions242
3 Marketed Products2616
  3.1 Overview261
  3.2 46TBisphosphonates261
    3.2.1 Risedronate Warner Chilcott262
    3.2.2 Alendronate Merck &Co281
    3.2.3 Boniva (ibandronate) Roche291
    3.2.4 Zoledronic Acid Novartis301
    3.2.5 Recalbon/Bonoteo (minodronate) Ono and Astellas Pharma311
    3.2.6 Etidronate Procter &Gamble and Sumitomo Pharmaceuticals321
  3.3 Dual-Acting Non-Bisphosphonates331
    3.3.1 Strontium Ranelate Servier331
  3.4 Selective Estrogen Receptor Modulators341
    3.4.1 Evista (raloxifene) Eli Lilly341
    3.4.2 Viviant (bazedoxifene) Ligand and Pfizer351
  3.5 Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Inhibitor361
    3.5.1 Prolia (denosumab) Amgen361
  3.6 Calcitonins371
    3.6.1 Calcitonin-salmon371
  3.7 Parathyroid Hormone381
    3.7.1 Forteo (teriparatide) Eli Lilly381
  3.8 Comparative Efficacy and Safety of Marketed Products393
4 Pipeline Analysis4219
  4.1 Overview421
  4.2 Pipeline by Stage of Development, Molecule Type, Route of Administration and Program Type432
  4.3 Pipeline by Molecular Target453
  4.4 Promising Pipeline Candidates481
    4.4.1 Romosozumab (AMG-785) Amgen483
    4.4.2 Abaloparatide-SC (BA-058-SC) Radius Health513
    4.4.3 Odanacatib (MK-0822 ) Merck &Co542
    4.4.4 Uni-PTH Uni-Bio Science562
  4.5 Comparative Efficacy and Safety of Pipeline Products581
  4.6 Product Competitiveness Framework592
5 Clinical Trial Analysis6112
  5.1 Failure Rate611
    5.1.1 Overall Failure Rate612
    5.1.2 Failure Rate by Phase and Molecule Type631
    5.1.3 Failure Rate by Phase and Molecular Target631
  5.2 Clinical Trial Duration641
    5.2.1 Clinical Trial Duration by Molecule Type642
    5.2.2 Clinical Trial Duration by Molecular Target661
  5.3 Clinical Trial Size671
    5.3.1 Patient Enrollment per Product by Molecule Type, Molecular Target and Stage of Development672
    5.3.2 Patient Enrollment per Trial by Molecule Type, Molecular Target and Stage of Development692
  5.4 Competitive Clinical Trials Metrics Analysis712
6 Multi-Scenario Forecast7319
  6.1 Geographical Markets731
  6.2 Asia-Pacific Market741
  6.3 India751
    6.3.1 Treatment Usage Patterns752
    6.3.2 Annual Cost of Therapy771
    6.3.3 Market Size781
  6.4 China791
    6.4.1 Treatment Usage Patterns791
    6.4.2 Annual Cost of Therapy801
    6.4.3 Market Size811
  6.5 Australia821
    6.5.1 Treatment Usage Patterns821
    6.5.2 Annual Cost of Therapy832
    6.5.3 Market Size851
  6.6 South Korea861
    6.6.1 Treatment Usage Patterns861
    6.6.2 Annual Cost of Therapy871
    6.6.3 Market Size881
  6.7 Japan891
    6.7.1 Treatment Usage Patterns891
    6.7.2 Annual Cost of Therapy891
    6.7.3 Market Size902
7 Drivers and Barriers923
  7.1 Drivers921
    7.1.1 Rising Prevalence921
    7.1.2 Increasing Health Insurance Coverage for Aged Population921
    7.1.3 Increasing Public and Policymaker Awareness921
    7.1.4 Promising Late-Stage Pipeline Products can Change the Treatment Paradigm931
  7.2 Barriers931
    7.2.1 Impending Patent Cliffs and Generic Erosion931
    7.2.2 Low Diagnosis and Treatment Rates931
    7.2.3 Non-Availability or Lack of Benefits for Combination Anabolic and Antiresorptive Therapies931
    7.2.4 Competition from Traditional Medicines941
8 Deals and Strategic Consolidations9511
  8.1 Licensing Deals951
    8.1.1 Deals by Region and Value951
    8.1.2 Number of Disclosed and Undisclosed Deals by Year, Aggregate Deal Value961
    8.1.3 Deal Value by Stage of Development, Molecule Type, and Molecular Target963
    8.1.4 Key Licensing Deals991
      8.1.4.1 Licensing Agreement between Sermonix and Ligand Pharmaceuticals991
      8.1.4.2 Licensing Agreement between Galapagos and Eli Lilly991
      8.1.4.3 Licensing Agreement between Dong Wha Pharma and Procter &Gamble1001
      8.1.4.4 Licensing Agreement between Nastech Pharma and Procter &Gamble1001
      8.1.4.5 Licensing Agreement between Daiichi Sankyo and Amgen1001
  8.2 Co-Development Deals1011
    8.2.1 Deals by Region and Value1011
    8.2.2 Number of Disclosed and Undisclosed Deals by Year, Aggregate Deal Value1021
    8.2.3 Deal Value by Stage of Development, Molecule Type, and Molecular Target1031
    8.2.4 Key Co-Development Deals1041
      8.2.4.1 Co-Development Agreement between Unigene Laboratories and GlaxoSmithKline1041
      8.2.4.2 Co-Development Agreement between Radius Health and 3M Drug Delivery Systems1041
      8.2.4.3 Co-Development Agreement between MorphoSys and Galapagos1041
      8.2.4.4 Co-Development Agreement between Interleukin and Access Business Group1041
      8.2.4.5 Co-Development Agreement between Chugai Pharma and Taisho Pharma1051
9 Appendix10626
  9.1 All Pipeline Drugs by Stage of Development1066
    9.1.1 Discovery1062
    9.1.2 Preclinical1082
    9.1.3 Investigational New Drug/ Clinical Trial Authorization-Filed1101
    9.1.4 Phase I1101
    9.1.5 Phase II1111
    9.1.6 Phase III1111
    9.1.7 Pre-registration1111
  9.2 Market Forecasts to 20211123
    9.2.1 Asia-Pacific1121
    9.2.2 India1121
    9.2.3 China1131
    9.2.4 Australia1131
    9.2.5 South Korea1141
    9.2.6 Japan1141
  9.3 Bibliography11511
  9.4 Abbreviations1261
  9.5 Research Methodology1275
    9.5.1 Secondary Research1281
    9.5.2 Marketed Product Profiles1281
    9.5.3 Late-Stage Pipeline Candidates1281
    9.5.4 Comparative Efficacy and Safety Heat Map for Marketed and Pipeline Products1291
    9.5.5 Product Competitiveness Framework1291
    9.5.6 Pipeline Analysis1291
      9.5.6.1 Overall Pipeline1291
      9.5.6.2 Clinical Trials1291
      9.5.6.3 Failure Rate1291
      9.5.6.4 Clinical Trial Size1301
      9.5.6.5 Clinical Trial Duration1301
      9.5.6.6 Clinical Trial Endpoint Analysis1301
    9.5.7 Forecasting Model1301
    9.5.8 Deals Data Analysis1311
  9.6 Contact Us1311
  9.7 Disclaimer1311

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MLA:
GBI Research Reports. "Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies" Jul 04, 2016. Alacra Store. Apr 16, 2024. <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Osteoporosis-Therapeutics-in-Asia-Pacific-Markets-to-2022-Growth-Driven-by-Rising-Prevalence-Growing-Awareness-and-Expected-Launch-of-Anabolic-Therapies-2115-728>
  
APA:
GBI Research Reports. (2016). Osteoporosis Therapeutics in Asia-Pacific Markets to 2022 - Growth Driven by Rising Prevalence, Growing Awareness and Expected Launch of Anabolic Therapies Jul 04, 2016. New York, NY: Alacra Store. Retrieved Apr 16, 2024 from <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Osteoporosis-Therapeutics-in-Asia-Pacific-Markets-to-2022-Growth-Driven-by-Rising-Prevalence-Growing-Awareness-and-Expected-Launch-of-Anabolic-Therapies-2115-728>
  
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