Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 4 | 7 |
List of Tables | 7 | 2 |
List of Figures | 9 | 2 |
Orphan Diseases Therapeutics in Oncology - Introduction | 11 | 4 |
Introduction | 11 | 1 |
Introduction to Cancer Etiology | 11 | 1 |
Drug Classes and their Mechanisms of Action in the Treatment of Cancer | 12 | 2 |
GBI Research Report Guidance | 14 | 1 |
Orphan Diseases Therapeutics in Oncology - Market Overview | 15 | 4 |
Revenues | 15 | 1 |
Annual Cost of Therapy | 16 | 1 |
Treatment Usage Pattern | 17 | 1 |
Diseased Population | 18 | 1 |
Diagnosed Population | 18 | 1 |
Prescription Population | 18 | 1 |
Orphan Diseases Therapeutics in Oncology - Geographical Landscape | 19 | 14 |
Introduction | 19 | 1 |
The US | 19 | 1 |
Sales Revenues | 19 | 2 |
ACT | 21 | 1 |
Treatment Usage Patterns | 22 | 1 |
Diseased Population | 23 | 1 |
Diagnosed Population | 23 | 1 |
Prescription Population | 23 | 1 |
Top Five Countries of Europe | 24 | 1 |
Sales Revenues | 24 | 2 |
ACT | 26 | 1 |
Treatment Usage Patterns | 27 | 1 |
Diseased Population | 28 | 1 |
Diagnosed Population | 28 | 1 |
Prescription Population | 28 | 1 |
Japan | 29 | 1 |
Sales Revenues | 29 | 1 |
ACT | 30 | 1 |
Treatment Usage Patterns | 31 | 1 |
Diseased Population | 32 | 1 |
Diagnosed Population | 32 | 1 |
Prescription Population | 32 | 1 |
Orphan Diseases Therapeutics in Oncology - Therapeutic Landscape | 33 | 37 |
Pancreatic Cancer Therapeutics Market | 33 | 1 |
Introduction | 33 | 1 |
Epidemiology | 33 | 1 |
Symptoms | 33 | 1 |
Treatment | 34 | 1 |
Sales Revenues | 34 | 2 |
ACT | 36 | 1 |
Treatment Usage Patterns | 37 | 1 |
Diseased Population | 38 | 1 |
Diagnosed Population | 38 | 1 |
Prescription Population | 38 | 1 |
Marketed Products | 38 | 1 |
Gemzar (gemcitabine) | 38 | 1 |
Tarceva (erlotinib) | 38 | 1 |
Drivers and Barriers in the Pancreatic Cancer Therapeutics Market | 39 | 1 |
Drivers | 39 | 1 |
Barriers | 40 | 1 |
Ovarian Cancer Therapeutics Market | 41 | 1 |
Introduction | 41 | 1 |
Epidemiology | 41 | 1 |
Symptoms | 41 | 1 |
Treatment | 41 | 1 |
Sales Revenues | 42 | 1 |
ACT | 43 | 1 |
Treatment Usage Patterns | 44 | 1 |
Diseased Population | 45 | 1 |
Diagnosed Population | 45 | 1 |
Prescription Population | 45 | 1 |
Marketed Products | 45 | 1 |
Topotecan | 45 | 1 |
Doxil (pegylated liposomal doxorubicin) | 45 | 1 |
Avastin (bevacizumab) | 45 | 1 |
Paclitaxel | 46 | 1 |
Carboplatin | 46 | 1 |
Drivers and Barriers in the Ovarian Cancer Therapeutics Market | 46 | 1 |
Drivers | 46 | 1 |
Barriers | 47 | 1 |
Multiple Myeloma Therapeutics Market | 47 | 1 |
Introduction | 47 | 1 |
Epidemiology | 47 | 1 |
Symptoms | 47 | 1 |
Treatment | 48 | 1 |
Sales Revenues | 49 | 1 |
ACT | 50 | 1 |
Treatment Usage Patterns | 51 | 1 |
Diseased Population | 52 | 1 |
Diagnosed Population | 52 | 1 |
Prescription Population | 52 | 1 |
Marketed Products | 52 | 1 |
Velcade (bortezomib) | 52 | 1 |
Revlimid (lenalidomide) | 53 | 1 |
Thalomid (thalidomide) | 53 | 1 |
Dexamethasone | 53 | 1 |
Prednisone | 53 | 1 |
Melphalan | 53 | 1 |
Cyclophosphamide | 53 | 1 |
Drivers and Barriers in the Multiple Myeloma Therapeutics Market | 54 | 1 |
Drivers | 54 | 1 |
Barriers | 54 | 1 |
Acute Myeloid Leukemia Therapeutics Market | 55 | 1 |
Introduction | 55 | 1 |
Epidemiology | 55 | 1 |
Symptoms | 55 | 1 |
Treatment | 56 | 1 |
Sales Revenues | 57 | 1 |
ACT | 58 | 1 |
Treatment Usage Patterns | 59 | 1 |
Diseased Population | 60 | 1 |
Diagnosed Population | 60 | 1 |
Prescription Population | 60 | 1 |
Marketed Products | 60 | 1 |
Vidaza (azacytidine) | 60 | 1 |
Cytarabine | 60 | 1 |
Daunorubicin | 60 | 1 |
Idarubicin | 61 | 1 |
Drivers and Barriers in the Acute Myeloid Leukemia Therapeutics Market | 61 | 1 |
Drivers | 61 | 1 |
Barriers | 62 | 1 |
Hodgkin Lymphoma Therapeutics Market | 62 | 1 |
Introduction | 62 | 1 |
Epidemiology | 62 | 1 |
Symptoms | 62 | 1 |
Treatment | 63 | 1 |
Sales Revenues | 64 | 1 |
ACT | 65 | 1 |
Treatment Usage Pattern | 66 | 1 |
Diseased Population | 67 | 1 |
Diagnosed Population | 67 | 1 |
Prescription Population | 67 | 1 |
Marketed Products | 67 | 1 |
Adcetris (Brentuximab vedotin) | 67 | 1 |
Doxorubicin | 67 | 1 |
Bleomycin | 67 | 1 |
Dacarbazine | 67 | 1 |
Procarbazine | 67 | 1 |
Vinblastine | 68 | 1 |
Vincristine | 68 | 1 |
7Etoposide | 68 | 1 |
Cyclophosphamide | 68 | 1 |
Drivers and Barriers in the Hodgkin Lymphoma Therapeutic Market | 68 | 1 |
Drivers | 69 | 1 |
Barriers | 69 | 1 |
Orphan Diseases Therapeutics in Oncology - Pipeline Analysis | 70 | 34 |
Introduction | 70 | 1 |
R&D Pipeline for Pancreatic Cancer | 71 | 1 |
Phase III | 72 | 1 |
Phase II | 72 | 1 |
Phase I | 73 | 1 |
IND Filed | 74 | 1 |
Preclinical | 75 | 2 |
Discovery | 77 | 1 |
Trends in the Pancreatic Cancer Developmental Pipeline | 77 | 1 |
Promising Pipeline Molecules | 78 | 1 |
FOLFIRINOX | 78 | 1 |
AMG-479 | 78 | 1 |
Masitinib | 78 | 1 |
R&D Pipeline for Ovarian Cancer | 79 | 1 |
Phase III | 80 | 1 |
Phase II | 81 | 2 |
Phase I | 83 | 1 |
Preclinical | 84 | 1 |
Discovery | 85 | 1 |
Trends in the Ovarian Cancer Developmental Pipeline | 85 | 1 |
Promising Pipeline Molecules | 86 | 1 |
EC145 | 86 | 1 |
Vargatef | 86 | 1 |
R&D Pipeline for Multiple Myeloma | 87 | 1 |
Phase III | 88 | 1 |
Phase II | 88 | 2 |
Phase I | 90 | 1 |
Preclinical | 91 | 1 |
Trends in the Multiple Myeloma Developmental Pipeline | 92 | 1 |
Promising Pipeline Molecules | 93 | 1 |
Pomalidomide | 93 | 1 |
Panobinostat | 93 | 1 |
Perifosine | 93 | 1 |
Carfilzomib | 93 | 1 |
R&D Pipeline for Acute Myeloid Leukemia | 94 | 1 |
Phase III | 95 | 1 |
Phase II | 95 | 2 |
Phase I | 97 | 1 |
Preclinical | 98 | 1 |
Discovery | 98 | 1 |
Trends in the Acute Myeloid Leukemia Developmental Pipeline | 99 | 1 |
Promising Pipeline Molecules | 100 | 1 |
Clolar (clofarabine) | 100 | 1 |
R&D Pipeline for Hodgkin Lymphoma | 100 | 1 |
NDA Filed | 101 | 1 |
Phase III | 101 | 1 |
Phase II | 101 | 1 |
Phase I | 102 | 1 |
Trends in the Hodgkin Lymphoma Developmental Pipeline | 102 | 1 |
Promising Pipeline Molecules | 103 | 1 |
Panobinostat | 103 | 1 |
Orphan Diseases Therapeutics in Oncology Therapeutics Market - Competitive Landscape | 104 | 5 |
Celgene Corporation | 104 | 1 |
SWOT Analysis | 104 | 1 |
Genentech, Inc. | 105 | 1 |
SWOT Analysis | 105 | 1 |
Amgen, Inc. | 106 | 1 |
SWOT Analysis | 106 | 1 |
Eli Lilly and Company | 107 | 1 |
SWOT Analysis | 107 | 1 |
Takeda Pharmaceutical Company Ltd. | 108 | 1 |
SWOT Analysis | 108 | 1 |
Orphan Diseases Therapeutics in Oncology - M&A, Licensing and Co-Development Landscape | 109 | 14 |
Overview | 109 | 1 |
M&A Landscape | 109 | 1 |
M&A Deals by Year | 109 | 1 |
M&A Deals by Geography | 110 | 1 |
M&A Deals by Value | 111 | 1 |
M&A Deals by Deal Type | 112 | 1 |
Major M&A Deals | 112 | 1 |
Sanofi Acquired Genzyme Corporation | 112 | 1 |
Takeda Pharmaceutical Company Acquires Millennium Pharmaceuticals | 112 | 1 |
Teva Pharmaceutical Industries Acquires Cephalon Inc. | 112 | 1 |
Fresenius Kabi AG Acquires APP Pharmaceuticals | 113 | 1 |
Astellas Pharma Acquires OSI Pharmaceuticals | 113 | 1 |
Celgene Corporation Acquires Abraxis Bioscience | 113 | 1 |
Celgene Corporation Acquires Pharmion Corporation | 113 | 1 |
Bristol-Myers Squibb Acquires Medarex, Inc. | 113 | 1 |
Amgen Inc. Acquires BioVex Group | 113 | 1 |
R&D Licensing Agreements | 114 | 1 |
Deals by Year | 114 | 1 |
Deals by Geography | 115 | 1 |
Deals by Value | 116 | 1 |
Major Licensing Agreements | 117 | 1 |
Genentech (Roche) Enters into Licensing Agreement with Seattle Genetics | 117 | 1 |
Bristol-Myers Squibb Enters into Licensing Agreement with Innate Pharma for IPH2102 | 117 | 1 |
Clavis Pharma Enters into Licensing Agreement with Clovis Oncology | 117 | 1 |
Onyx Pharmaceuticals Enters into Licensing Agreement with Ono Pharmaceutical for Carfilzomib and ONX 0912 | 117 | 1 |
Clinical Data Enters into Licensing Agreement with CombinatoRx | 118 | 1 |
Clovis Oncology Enters into Licensing Agreement with Pfizer for PF-01367338 | 118 | 1 |
4SC Enters into Licensing Agreement with Yakult Honsha for Resminostat | 118 | 1 |
Co-Development Agreements | 119 | 1 |
Deals by Year | 119 | 1 |
Deals by Geography | 120 | 1 |
Deals by Value | 121 | 1 |
Major Co-Development Agreements | 122 | 1 |
Bristol-Myers Squibb Enters into an Agreement with PDL BioPharma | 122 | 1 |
Ambit Biosciences Enters into Co-Development Agreement with Astellas Pharma | 122 | 1 |
Orphan Diseases Therapeutics in Oncology - Appendix | 123 | 6 |
Market Definitions | 123 | 1 |
Abbreviations | 123 | 1 |
Sources | 124 | 1 |
Research Methodology | 124 | 5 |
Coverage | 124 | 1 |
Secondary Research | 124 | 1 |
Primary Research | 125 | 1 |
Therapeutic Landscape | 125 | 1 |
Epidemiology-based Forecasting | 125 | 2 |