Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 3 | 6 |
List of Tables | 5 | 2 |
List of Figures | 7 | 2 |
Orphan Diseases Therapeutics in CNS - Introduction | 9 | 2 |
GBI Research Report Guidance | 10 | 1 |
Orphan Diseases Therapeutics in CNS - Market Overview | 11 | 12 |
Introduction | 11 | 1 |
Orphan Disease Regulation and Incentives | 11 | 2 |
Global Revenue Forecasts for Orphan Diseases Therapeutics in CNS | 13 | 1 |
Global Revenue and Forecast | 13 | 2 |
Geographical Segmentation | 15 | 2 |
Branded and Generic Market Share | 17 | 1 |
Revenue Share by Indication | 18 | 2 |
Market Drivers | 20 | 1 |
Regulatory Incentives will Encourage R&D | 20 | 1 |
Targeting Non-Orphan Indications with Orphan Drugs Increases Market Potential for Orphan Drugs | 20 | 1 |
Generic Drugs are not a Threat to Disease-Modifying Therapies | 21 | 1 |
Market Restraints | 21 | 1 |
Conducting Clinical Trials for Orphan Diseases in the CNS is Difficult | 21 | 1 |
CNS Diseases are Poorly Understood and this Hinders Drug Development | 21 | 1 |
Unmet Needs | 21 | 1 |
Opportunities | 22 | 1 |
Orphan Diseases Therapeutics in CNS - Geographical Landscape | 23 | 4 |
The US | 23 | 1 |
Revenue | 23 | 2 |
Top Five Countries of Europe | 25 | 1 |
Revenue | 25 | 1 |
Japan | 26 | 1 |
Revenue | 26 | 1 |
Orphan Diseases in CNS Disorders - Therapeutic Landscape | 27 | 44 |
Amyotrophic Lateral Sclerosis | 27 | 1 |
Disease Overview | 27 | 1 |
Revenue | 27 | 4 |
Average Annual Cost of Treatment | 31 | 2 |
Branded and Generic Market Share | 33 | 1 |
Treatment Algorithm | 34 | 1 |
Treatment Usage Patterns | 34 | 1 |
Diseased Population | 34 | 2 |
Treatment Seeking Population | 36 | 2 |
Diagnosed Population | 38 | 2 |
Prescription Population | 40 | 1 |
Approved Molecules | 41 | 1 |
Rilutek | 41 | 1 |
Mechanism of Action | 41 | 1 |
Efficacy Details | 41 | 1 |
Safety Profile | 41 | 1 |
Cost of Therapy | 42 | 1 |
Nuedexta (Dextromethorphan Hydrobromide and Quinidine Sulfate) | 42 | 1 |
Mechanism of Action | 42 | 1 |
Efficacy | 42 | 1 |
Safety | 42 | 1 |
Cost of Therapy | 43 | 1 |
Huntington s Disease | 43 | 1 |
Disease Overview | 43 | 1 |
Total Revenue | 44 | 3 |
Average Annual Cost of Treatment (ACT) | 47 | 1 |
Branded and Generic Market Share | 48 | 1 |
Treatment Algorithm | 49 | 1 |
Treatment Usage Patterns | 50 | 1 |
Diseased Population | 50 | 1 |
Treatment Seeking Population | 51 | 1 |
Diagnosed Population | 52 | 1 |
Prescription Population | 53 | 1 |
Approved Molecules | 54 | 1 |
Xenazine (tetrabenazine) | 54 | 1 |
Mechanism of Action | 54 | 1 |
Efficacy Details | 54 | 1 |
Safety Profile | 54 | 1 |
Cost of Therapy | 55 | 1 |
Myasthenia Gravis | 55 | 1 |
Disease Overview | 55 | 1 |
Total Revenue | 56 | 3 |
Branded and Generic Market Share | 59 | 1 |
Average Annual Cost of Treatment | 60 | 1 |
Treatment Algorithm | 61 | 1 |
Treatment Usage Patterns | 62 | 1 |
Diseased Population | 62 | 1 |
Treatment Seeking Population | 63 | 1 |
Diagnosed Population | 64 | 1 |
Prescription Population | 65 | 1 |
Approved Molecules | 66 | 1 |
Prograf (Tacrolimus) | 66 | 1 |
Other Indications | 67 | 1 |
Total Revenue | 67 | 1 |
Product Profiles | 68 | 1 |
Apokyn (Apomorphine Hydrochloride) | 68 | 1 |
Diacomit (Stiripentol) | 68 | 1 |
Banzel (Rufinamide) | 69 | 1 |
Lamictal (Lamotrigine) | 69 | 1 |
Modafinil | 70 | 1 |
Prialt (Ziconotide Intrathecal Infusion) | 70 | 1 |
Global Orphan Diseases in CNS Disorders - Pipeline Analysis | 71 | 14 |
Introduction | 71 | 1 |
Research and Development Pipeline | 72 | 1 |
Overview | 72 | 3 |
Pipeline by Clinical Phases of Development | 75 | 1 |
Discovery | 75 | 1 |
Pre-clinical | 76 | 2 |
IND Filed | 78 | 1 |
Phase I | 79 | 1 |
Phase II | 80 | 1 |
Phase III | 81 | 1 |
Profiles of Promising Drugs in Orphan Diseases in CNS Disorders | 82 | 1 |
CK-2017357 | 82 | 1 |
Dexpramipexole | 82 | 1 |
NP001 | 82 | 1 |
TRO19622 (Olesoxime) | 82 | 1 |
Huntexil | 83 | 1 |
AMR 101 | 83 | 1 |
HD-02 | 83 | 1 |
SEN196 | 83 | 1 |
Venoglobulin-IH | 83 | 1 |
Revimmune | 84 | 1 |
Soliris (Eculizumab) | 84 | 1 |
Global Orphan Diseases in CNS Disorders - Competitive Landscape | 85 | 10 |
Major Players | 85 | 1 |
Major Company Profiles | 85 | 1 |
Biogen Idec | 85 | 1 |
SWOT Analysis | 85 | 1 |
Avanir | 86 | 1 |
SWOT Analysis | 86 | 1 |
Neuraltus | 87 | 1 |
SWOT Analysis | 87 | 1 |
Cytokinetics | 88 | 1 |
SWOT Analysis | 88 | 1 |
Avicena | 89 | 1 |
SWOT Analysis | 89 | 1 |
NeuroSearch | 90 | 1 |
SWOT Analysis | 90 | 1 |
Trophos | 91 | 1 |
SWOT Analysis | 91 | 1 |
Amarin | 92 | 1 |
SWOT Analysis | 92 | 1 |
Siena Biotech | 93 | 1 |
SWOT Analysis | 93 | 1 |
Sanofi | 94 | 1 |
SWOT Analysis | 94 | 1 |
Global Orphan Diseases in CNS Disorders - Strategic Consolidations | 95 | 21 |
Mergers and Acquisitions | 95 | 1 |
Overview | 95 | 2 |
Major Mergers and Acquisitions Deals | 97 | 1 |
H. Lundbeck Acquires LifeHealth | 97 | 1 |
H. Lundbeck Acquires OVATION Pharmaceuticals | 97 | 1 |
CytRx Acquires Clinical and Pharmaceutical Assets from Biorex | 97 | 1 |
Pfizer Acquires FoldRx Pharmaceuticals | 97 | 1 |
Segmentation by Indication | 98 | 1 |
Segmentation by Geography | 99 | 1 |
Segmentation by Deal Value | 100 | 1 |
Segmentation by Year | 101 | 1 |
Licensing Agreements | 102 | 1 |
Overview | 102 | 3 |
Major Licensing Deals | 105 | 1 |
NeuroSearch Terminates Licensing Agreement with Astellas Pharma for the Rights for ACR16 | 105 | 1 |
Biovail Acquires Rights for Tetrabenazine and Related Assets from Cambridge Laboratories | 105 | 1 |
Biogen Idec Enters into Licensing Agreement with Knopp Neurosciences for KNS-760704 | 106 | 1 |
Brain Science Institute Enters into Licensing Agreement with Eisai | 106 | 1 |
Debiopharm Enters into Licensing Agreement with DeveloGen | 106 | 1 |
Amorfix Life Sciences Enters into Licensing Agreement with Biogen Idec | 106 | 1 |
Segmentation by Indication | 107 | 1 |
Segmentation by Geography | 108 | 1 |
Segmentation by Deal Value | 109 | 1 |
Segmentation by Year | 110 | 1 |
Co Development Deals | 111 | 2 |
Segmentation by Geography | 113 | 1 |
Segmentation by Value | 114 | 1 |
Segmentation by Year | 115 | 1 |
CNS Orphan Diseases - Appendix | 116 | 9 |
Market Definition | 116 | 1 |
Abbreviations | 116 | 1 |
Research Methodology | 117 | 2 |
Coverage | 118 | 1 |
Secondary Research | 118 | 1 |
Primary Research | 118 | 1 |
Forecasting | 119 | 2 |
Epidemiology-based Forecasting | 119 | 1 |
Expert Panels Validation | 120 | 1 |
Contact Us | 120 | 1 |
Disclaimer | 120 | 1 |
Sources | 120 | 5 |