Sections
Title | Starting Page | Number of Pages |
---|
Table of Contents | 6 | 6 |
List of Tables | 9 | 1 |
List of Figures | 10 | 2 |
Introduction | 12 | 17 |
Symptoms | 12 | 1 |
Etiology | 13 | 1 |
Pathophysiology | 13 | 1 |
Disease Initiation | 13 | 1 |
Disease Propagation | 14 | 1 |
Co-Morbidities and Complications | 15 | 1 |
Diagnosis | 16 | 1 |
Physical Examination | 16 | 1 |
Blood Tests | 16 | 1 |
Rheumatoid Factor Test | 16 | 1 |
Anti-Citrullinated Protein Antibody | 16 | 1 |
C-Reactive Protein | 16 | 1 |
Erythrocyte Sedimentation Rate | 16 | 1 |
X-Ray Imaging | 17 | 1 |
Classification | 17 | 2 |
Epidemiology | 19 | 1 |
Prognosis and Disease Staging | 19 | 1 |
Measurement of Treatment Effectiveness | 20 | 1 |
Treatment Options | 21 | 1 |
Pharmacological | 21 | 1 |
Disease-Modifying Anti-Rheumatic Drugs | 21 | 1 |
Methotrexate | 21 | 1 |
Celebrex (celecoxib) | 21 | 1 |
Plaquenil (hydroxychloroquine) | 22 | 1 |
Arava (leflunomide) | 22 | 1 |
Azulfidine, Salazopyrin (sulfasalazine) | 22 | 1 |
Neoral (cyclosporine) | 22 | 1 |
Prograf (tacrolimus) | 22 | 1 |
Xeljanz (tofacitinib) | 22 | 1 |
Other Nonbiologics | 23 | 1 |
Non-Steroidal Anti Inflammatory Drugs | 23 | 1 |
Painkillers | 23 | 1 |
Glucocorticoids | 23 | 1 |
Biologic Disease-Modifying Anti-Rheumatic Drugs | 23 | 1 |
| 24 | 1 |
Interleukin-6 Inhibitors | 24 | 1 |
Other Monoclonal Antibodies | 24 | 1 |
Anakinra | 25 | 1 |
Treatment Algorithms and Prescribing Habits | 25 | 3 |
Non-Pharmacological Care | 28 | 1 |
Marketed Products | 29 | 19 |
Therapeutic Landscape | 30 | 1 |
Remicade (infliximab) - Johnson and Johnson, Merck | 30 | 2 |
Humira (adalimumab) - Abbott Laboratories | 32 | 2 |
Enbrel (etanercept) - Amgen Inc., Pfizer Inc. and Takeda Pharmaceutical Co. Ltd. | 34 | 2 |
Rituxan (rituximab) - Genentech (Roche Group), Biogen IDEC Inc. | 36 | 2 |
Orencia (abatacept) - Bristol-Myers Squibb | 38 | 2 |
Actemra (tocilizumab) -F Hoffman La Roche Ltd. | 40 | 2 |
Simponi (golimumab) - Johnson and Johnson, Merck | 42 | 1 |
Cimzia (certolizumab pegol) - UCB S.A. | 43 | 1 |
Remsima (biosimilar infliximab) - Celltrion Inc. | 44 | 1 |
Comparative Efficacy and Safety | 44 | 3 |
Unmet Need | 47 | 1 |
Pipeline for Rheumatoid Arthritis Monoclonal Antibody Therapeutics | 48 | 20 |
Overall Pipeline | 48 | 1 |
Molecular Targets in the Pipeline | 49 | 3 |
Clinical Trials | 52 | 1 |
Failure Rate | 52 | 4 |
Patient Enrolment and Clinical Trial Size | 56 | 3 |
Duration | 59 | 2 |
Promising Drug Candidates in the Pipeline | 61 | 1 |
Arzerra (ofatumumab) - Genmab A/S, GlaxoSmithKline Plc. | 61 | 1 |
LY2127399 (tabalumab) - Eli Lily and Company | 61 | 1 |
REGN88 (sarilumab) - Regeneron Pharmaceuticals Inc. | 62 | 1 |
CNTO 136 (sirukumab) - Johnson and Johnson | 62 | 1 |
AIN457 (secukinumab) - Novartis | 63 | 1 |
ALD-518 - Alder Biopharmaceuticals Inc. | 63 | 1 |
BT-061 (tregalizumab) - Biotest A.G. | 63 | 1 |
MLTA3698A (pateclizumab) - Genentech Inc. | 64 | 1 |
MOR 103 - MorphoSys A.G. | 64 | 1 |
Heat Map of Safety and Efficacy for Pipeline and Marketed Products | 65 | 1 |
Conclusion | 66 | 2 |
Market Forecast to 2018 | 68 | 22 |
Geographical Markets | 68 | 1 |
Global Market | 69 | 2 |
US | 71 | 1 |
Treatment Usage Patterns | 71 | 1 |
Annual Cost of Treatment | 71 | 1 |
Market Size | 71 | 2 |
UK | 73 | 1 |
Treatment Usage Patterns | 73 | 1 |
Annual Cost of Treatment | 73 | 1 |
Market Size | 73 | 2 |
France | 75 | 1 |
Treatment Usage Patterns | 75 | 1 |
Annual Cost of Treatment | 75 | 1 |
Market Size | 75 | 2 |
Germany | 77 | 1 |
Treatment Usage Patterns | 77 | 1 |
Annual Cost of Treatment | 77 | 1 |
Market Size | 77 | 2 |
Italy | 79 | 1 |
Treatment Usage Patterns | 79 | 1 |
Annual Cost of Treatment | 79 | 1 |
Market Size | 79 | 2 |
Spain | 81 | 1 |
Treatment Usage Patterns | 81 | 1 |
Annual Cost of Treatment | 81 | 1 |
Market Size | 81 | 2 |
Japan | 83 | 1 |
Treatment Usage Patterns | 83 | 1 |
Annual Cost of Treatment | 83 | 1 |
Market Size | 83 | 2 |
Drivers and Barriers for the mAbs market in Rheumatoid Arthritis | 85 | 1 |
Drivers | 85 | 1 |
Repositioning as a Supplementary Revenue Source | 85 | 1 |
Weak Sales Erosion by Biosimilars | 86 | 1 |
High Annual Cost of Treatment Still Rising | 87 | 1 |
Sustained Innovation in Developmental Pipeline | 87 | 1 |
Barriers | 87 | 1 |
Difficulty and Expense in the Production of mAbs | 87 | 1 |
Safety Concerns | 88 | 1 |
Impending Patent Cliffs | 88 | 2 |
Deals and Strategic Consolidations | 90 | 11 |
Mergers and Acquisition Deals | 91 | 1 |
Amgen Completes Acquisition of Micromet, Inc. | 91 | 1 |
Pfizer Inc. Completes Acquisition of Wyeth | 92 | 1 |
Bristol-Myers Squibb Completes Acquisition of Medarex Inc. | 92 | 1 |
Teva Pharmaceutical Industries Limited Acquires CoGenesys Inc. | 92 | 1 |
Biotie Therapies Corp. Terminates Acquisition of Newron Pharmaceuticals S.p.A. | 92 | 1 |
Emergent BioSolutions Inc. Completes Acquisition of Trubion Pharmaceuticals Inc. | 92 | 1 |
Alexion Pharmaceuticals Inc. completes acquisition of Taligen Therapeutics Inc. | 93 | 1 |
Ligand Pharmaceuticals Incorporated Completes Acquisition of Pharmacopeia Inc. | 93 | 1 |
Astellas Pharma Inc. Completes Acquisition of Perseid Therapeutics LLC | 93 | 1 |
Cypress Bioscience Inc. Completes Acquisition of Proprius Pharmaceuticals Inc. | 93 | 1 |
Simcere Pharmaceutical Group Completes Acquisition of Shanghai Celgen Bio-Pharmaceutical Co. Ltd. | 93 | 1 |
Major Co-development Deals | 94 | 1 |
Abbott Laboratories Enters Worldwide Agreement with Biotest AG | 94 | 1 |
Dynavax Technologies Corporation Expands Worldwide Agreement with GlaxoSmithKline plc | 95 | 1 |
Astellas Pharma Inc. Enters into Agreement with Maxygen Inc. | 95 | 1 |
Tanabe Research Laboratories Enters Agreement with Anaphore Inc. | 95 | 1 |
Major Licensing Deals | 96 | 3 |
Hanwha Chemical Corporation Enter Licensing Agreement with Merck Sharp and Dohme Research Ltd. | 99 | 1 |
Alder Biopharmaceuticals Inc. Enter Agreement with Bristol-Myers Squibb Company | 99 | 1 |
Immunomedics Inc. Enter Agreement with Nycomed International Management GmbH | 99 | 1 |
Sanofi-Aventis Enter Agreement with Kyowa Hakko Kogyo Co. Ltd. | 99 | 1 |
EUSA Pharma Inc. Enter Licensing Agreement with GlaxoSmithKline plc | 100 | 1 |
Appendix | 101 | 34 |
All Pipeline Drugs by Phase | 101 | 11 |
Discovery | 101 | 1 |
Preclinical | 102 | 4 |
IND-Filed and Phase 0 | 106 | 1 |
Phase I | 106 | 2 |
Phase II | 108 | 2 |
Phase III | 110 | 1 |
Undisclosed | 111 | 1 |
Market Forecasts to 2018 | 112 | 9 |
Global | 112 | 1 |
United States | 113 | 1 |
Top Five European Countries (Aggregate) | 114 | 1 |
UK | 115 | 1 |
France | 116 | 1 |
Germany | 117 | 1 |
Italy | 118 | 1 |
Spain | 119 | 1 |
Japan | 120 | 1 |
Market Definitions | 121 | 1 |
Abbreviations | 121 | 2 |
References for Heat Maps (Figure 12 and Figure 23) | 123 | 2 |
Sources | 125 | 5 |
Research Methodology | 130 | 5 |
Coverage | 130 | 1 |
Secondary Research | 130 | 1 |
Primary Research | 131 | 1 |
Therapeutic Landscape | 131 | 1 |
Epidemiology-Based Forecasting | 132 | 1 |
Market Size by Geography | 133 | 1 |
Geographical Landscape | 134 | 1 |
Pipeline Analysis | 134 | 1 |
Expert Panel Validation | 134 | 1 |
Contact Us | 134 | 1 |
Disclaimer | 134 | 1 |