Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion - GBI Research Reports

Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion

Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion - GBI Research Reports
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion
Published Jan 31, 2013
134 pages — Published Jan 31, 2013
Price US$ 3,500.00  |  Buy this Report Now

About This Report

  
Abstract:

Summary

GBI Research, the leading business intelligence provider, has released its latest research, Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion. The currently marketed monoclonal antibodies are clinically and commercially highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. The unique density of monoclonal antibodies that are approved for this indication, significant market exclusivity expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.

Scope

- The current therapeutic environment in the treatment of RA across the top seven developed markets, including the US, Germany, France, the UK, Italy, Spain and Japan.
- Analysis of the competitive environment for monoclonal antibodies with strong data and evidence-based profiling of marketed products, including comparative benchmarking and assessment of efficacy and safety profiles as well as differentiating product features.
- A detailed pipeline analysis for monoclonal antibodies in rheumatoid arthritis including individual product profiles, a comparative efficacy and safety profile heat map analysis of the most promising pipeline products as well as analyses on the distribution of molecule types across the RA developmental pipeline, the molecular targets of pipeline mAbs and the developmental program types. In addition, detailed analyses of the clinical trial failure rates, the clinical trial durations by phase and clinical trial sizes by participant numbers are provided.
- Market data on the geographical landscape and therapeutic landscape, including market size, annual cost of therapy, treatment usage patterns such as disease population and prescription populations.
- Market forecasts across the US, the top five countries in Europe (EU5) - Germany, France, the UK, Italy, and Spain- as well as Japan. The multiple scenario forecasts take a range of factors that are likely to vary into account and provide a clear perspective on the level of the potential degree of variance in the market sizes.
- Key market drivers and barriers
- the major deals that have taken place in the monoclonal antibodies market in rheumatoid arthritis in recent years. Coverage includes Mergers and Acquisitions (M&As) as well as co-development and licensing agreements, which are segmented on the basis of geography and total value. A concomitant analysis of the licensing deal values for products by molecule types and molecular targets is also provided.

Reasons to buy

- Understand the competitive environment for monoclonal antibodies
- Develop key strategic repositioning initiatives by studying the repositioning trends and strategies of current competitors
- Understand the clinical and commercial impact of the growing diversification of the molecular targets of monoclonal antibodies in the pipeline and identify potential first-in-class products
- Assess the potential clinical and commercial impact of current late-stage pipeline molecules on the RA market in the forecast period
- Use the clinical trial failure rate analysis to assess the risk profiles of current and/or future developmental programs for monoclonal antibodies in RA
- Use key benchmark data to forecast costs of developmental programs for monoclonal antibodies in RA by using proprietary clinical trial size and duration analyses
- Exploit in-licensing and out-licensing opportunities by identifying products that might fill their portfolio gaps
- Use proprietary data analyses to assess the market value of pi

  
Source:
Document ID
GBIHC273MR
Industry
Format:
PDF Adobe Acrobat
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Sections

TitleStarting PageNumber of Pages
Table of Contents66
  List of Tables91
  List of Figures102
Introduction1217
  Symptoms121
  Etiology131
  Pathophysiology131
    Disease Initiation131
    Disease Propagation141
  Co-Morbidities and Complications151
  Diagnosis161
    Physical Examination161
    Blood Tests161
      Rheumatoid Factor Test161
      Anti-Citrullinated Protein Antibody161
      C-Reactive Protein161
      Erythrocyte Sedimentation Rate161
    X-Ray Imaging171
  Classification172
  Epidemiology191
  Prognosis and Disease Staging191
  Measurement of Treatment Effectiveness201
  Treatment Options211
    Pharmacological211
      Disease-Modifying Anti-Rheumatic Drugs211
        Methotrexate211
        Celebrex (celecoxib)211
        Plaquenil (hydroxychloroquine)221
        Arava (leflunomide)221
        Azulfidine, Salazopyrin (sulfasalazine)221
        Neoral (cyclosporine)221
        Prograf (tacrolimus)221
        Xeljanz (tofacitinib)221
      Other Nonbiologics231
        Non-Steroidal Anti Inflammatory Drugs231
        Painkillers231
        Glucocorticoids231
      Biologic Disease-Modifying Anti-Rheumatic Drugs231
         241
        Interleukin-6 Inhibitors241
        Other Monoclonal Antibodies241
        Anakinra251
    Treatment Algorithms and Prescribing Habits253
    Non-Pharmacological Care281
Marketed Products2919
  Therapeutic Landscape301
    Remicade (infliximab) - Johnson and Johnson, Merck302
    Humira (adalimumab) - Abbott Laboratories322
    Enbrel (etanercept) - Amgen Inc., Pfizer Inc. and Takeda Pharmaceutical Co. Ltd.342
    Rituxan (rituximab) - Genentech (Roche Group), Biogen IDEC Inc.362
    Orencia (abatacept) - Bristol-Myers Squibb382
    Actemra (tocilizumab) -F Hoffman La Roche Ltd.402
    Simponi (golimumab) - Johnson and Johnson, Merck421
    Cimzia (certolizumab pegol) - UCB S.A.431
    Remsima (biosimilar infliximab) - Celltrion Inc.441
  Comparative Efficacy and Safety443
  Unmet Need471
Pipeline for Rheumatoid Arthritis Monoclonal Antibody Therapeutics4820
  Overall Pipeline481
  Molecular Targets in the Pipeline493
  Clinical Trials521
    Failure Rate524
    Patient Enrolment and Clinical Trial Size563
    Duration592
  Promising Drug Candidates in the Pipeline611
    Arzerra (ofatumumab) - Genmab A/S, GlaxoSmithKline Plc.611
    LY2127399 (tabalumab) - Eli Lily and Company611
    REGN88 (sarilumab) - Regeneron Pharmaceuticals Inc.621
    CNTO 136 (sirukumab) - Johnson and Johnson621
    AIN457 (secukinumab) - Novartis631
    ALD-518 - Alder Biopharmaceuticals Inc.631
    BT-061 (tregalizumab) - Biotest A.G.631
    MLTA3698A (pateclizumab) - Genentech Inc.641
    MOR 103 - MorphoSys A.G.641
  Heat Map of Safety and Efficacy for Pipeline and Marketed Products651
  Conclusion662
Market Forecast to 20186822
  Geographical Markets681
    Global Market692
    US711
      Treatment Usage Patterns711
      Annual Cost of Treatment711
      Market Size712
    UK731
      Treatment Usage Patterns731
      Annual Cost of Treatment731
      Market Size732
    France751
      Treatment Usage Patterns751
      Annual Cost of Treatment751
      Market Size752
    Germany771
      Treatment Usage Patterns771
      Annual Cost of Treatment771
      Market Size772
    Italy791
      Treatment Usage Patterns791
      Annual Cost of Treatment791
      Market Size792
    Spain811
      Treatment Usage Patterns811
      Annual Cost of Treatment811
      Market Size812
    Japan831
      Treatment Usage Patterns831
      Annual Cost of Treatment831
      Market Size832
  Drivers and Barriers for the mAbs market in Rheumatoid Arthritis851
    Drivers851
      Repositioning as a Supplementary Revenue Source851
      Weak Sales Erosion by Biosimilars861
      High Annual Cost of Treatment Still Rising871
      Sustained Innovation in Developmental Pipeline871
    Barriers871
      Difficulty and Expense in the Production of mAbs871
      Safety Concerns881
      Impending Patent Cliffs882
Deals and Strategic Consolidations9011
  Mergers and Acquisition Deals911
    Amgen Completes Acquisition of Micromet, Inc.911
    Pfizer Inc. Completes Acquisition of Wyeth921
    Bristol-Myers Squibb Completes Acquisition of Medarex Inc.921
    Teva Pharmaceutical Industries Limited Acquires CoGenesys Inc.921
    Biotie Therapies Corp. Terminates Acquisition of Newron Pharmaceuticals S.p.A.921
    Emergent BioSolutions Inc. Completes Acquisition of Trubion Pharmaceuticals Inc.921
    Alexion Pharmaceuticals Inc. completes acquisition of Taligen Therapeutics Inc.931
    Ligand Pharmaceuticals Incorporated Completes Acquisition of Pharmacopeia Inc.931
    Astellas Pharma Inc. Completes Acquisition of Perseid Therapeutics LLC931
    Cypress Bioscience Inc. Completes Acquisition of Proprius Pharmaceuticals Inc.931
    Simcere Pharmaceutical Group Completes Acquisition of Shanghai Celgen Bio-Pharmaceutical Co. Ltd.931
  Major Co-development Deals941
    Abbott Laboratories Enters Worldwide Agreement with Biotest AG941
    Dynavax Technologies Corporation Expands Worldwide Agreement with GlaxoSmithKline plc951
    Astellas Pharma Inc. Enters into Agreement with Maxygen Inc.951
    Tanabe Research Laboratories Enters Agreement with Anaphore Inc.951
  Major Licensing Deals963
    Hanwha Chemical Corporation Enter Licensing Agreement with Merck Sharp and Dohme Research Ltd.991
    Alder Biopharmaceuticals Inc. Enter Agreement with Bristol-Myers Squibb Company991
    Immunomedics Inc. Enter Agreement with Nycomed International Management GmbH991
    Sanofi-Aventis Enter Agreement with Kyowa Hakko Kogyo Co. Ltd.991
    EUSA Pharma Inc. Enter Licensing Agreement with GlaxoSmithKline plc1001
Appendix10134
  All Pipeline Drugs by Phase10111
    Discovery1011
    Preclinical1024
    IND-Filed and Phase 01061
    Phase I1062
    Phase II1082
    Phase III1101
    Undisclosed1111
  Market Forecasts to 20181129
    Global1121
    United States1131
    Top Five European Countries (Aggregate)1141
    UK1151
    France1161
    Germany1171
    Italy1181
    Spain1191
    Japan1201
  Market Definitions1211
  Abbreviations1212
  References for Heat Maps (Figure 12 and Figure 23)1232
  Sources1255
  Research Methodology1305
    Coverage1301
    Secondary Research1301
    Primary Research1311
    Therapeutic Landscape1311
      Epidemiology-Based Forecasting1321
      Market Size by Geography1331
    Geographical Landscape1341
    Pipeline Analysis1341
  Expert Panel Validation1341
  Contact Us1341
  Disclaimer1341

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Cite this Report

  
MLA:
GBI Research Reports. "Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion" Jan 31, 2013. Alacra Store. May 04, 2025. <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Monoclonal-Antibodies-Market-in-Rheumatoid-Arthritis-to-2018-Market-Characterized-by-Large-and-Diversified-Pipeline-and-Low-Threat-of-Biosimilar-Sales-Erosion-2115-565>
  
APA:
GBI Research Reports. (2013). Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 - Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion Jan 31, 2013. New York, NY: Alacra Store. Retrieved May 04, 2025 from <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Monoclonal-Antibodies-Market-in-Rheumatoid-Arthritis-to-2018-Market-Characterized-by-Large-and-Diversified-Pipeline-and-Low-Threat-of-Biosimilar-Sales-Erosion-2115-565>
  
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