Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period - GBI Research Reports

Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period

Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period - GBI Research Reports
Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period
Published Aug 01, 2016
150 pages — Published Aug 01, 2016
Price US$ 4,995.00  |  Buy this Report Now

About This Report

  
Abstract:

Summary

Ophthalmology is a therapy area that deals with the diagnosis, treatment and prevention of diseases associated with the eyes and visual system. Most eye disorders occur over a long period of time, and are initially asymptomatic or cause only a slight decrease in vision. However, over time this becomes quite marked. Ophthalmologic disorders cannot currently be cured, and treatment is aimed at managing the disease indication in order to reduce the severity of symptoms and slow progression.

Angiogenesis inhibitors are the most effective and most common therapies used in ophthalmology; this class of compounds has been the most commercially successful in the past decade, with products such as Eylea and Lucentis generating strong annual revenues. Although there are many generics available across the majority of ophthalmology disorders, there are a number of premium products that attract substantial revenues - in particular Eylea, Lucentis, Lumigan and Restasis. The report focuses on five key indications within ophthalmology: glaucoma, age-related macular degeneration (AMD), diabetic macular edema, diabetic retinopathy and dry eye syndrome. There are currently no therapeutic options available for the treatment of dry AMD, increasing the need for extensive R&D within this area.

Although there is a high degree of failure and uncertainty within the R&D of ophthalmology drugs, the number of drugs in the pipeline is very high, at 734. The majority of pipeline products are novel active pharmaceutical ingredients, with only a small proportion of products being either generics or repositioned from other indications. This shows progression in terms of the variety of different molecules being developed as therapeutic agents within the ophthalmology pipeline. The expected growth of the ophthalmology market over the forecast period is attributed to the approval of new drugs, as well as rising prevalence.

Scope

- Global revenues for the ophthalmology market are forecast to grow at a compound annual growth rate of 9.48%, from $13.7 billion in 2015 to $26 billion in 2022. Which drugs will achieve blockbuster status and how will the key player companies perform during the forecast period?
- The ophthalmology pipeline is large and diverse, and contains 734 products. How does the composition of the pipeline compare with that of the existing market?
- What mechanisms of action and molecule types are most commonly being trialed in pipeline products in the various key indications?
- Which products will contribute to market growth most significantly, and which will achieve blockbuster status?
- Will the current market leaders retain their dominance over the forecast period, and how is their revenue share of the dermatology market set to change?

Reasons to buy

This report will allow you to -
- Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis
- Visualize the composition of the ophthalmology market across each indication, in terms of dominant molecule types and targets, highlighting the key commercial assets and players
- Analyze the ophthalmology pipeline and stratify by stage of development, molecule type and molecular target, with a granular breakdown across key indications
- Understand the growth in patient epidemiology and market revenues for the ophthalmology market, globally and across the key players and product types
- Stratify the market in terms of the split between generic and premium products, and assess the role of these product types in the treatment of the various ophthalmology disorders.
- Identify commercial opportunities in the urological cancer deal

  
Source:
Document ID
GBIHC388MR
Industry
Format:
PDF Adobe Acrobat
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Sections

TitleStarting PageNumber of Pages
1 Table of Contents45
  1.1 List of Tables61
  1.2 List of Figures63
2 Introduction920
  2.1 Therapy Area Introduction91
    2.1.1 Glaucoma91
    2.1.2 63TAge-Related Macular Degeneration91
    2.1.3 Diabetic Macular Edema101
    2.1.4 Diabetic Retinopathy101
    2.1.5 Dry Eye Syndrome101
  2.2 Symptoms112
  2.3 Etiology and Pathophysiology131
    2.3.1 Etiology132
    2.3.2 Pathophysiology151
      2.3.2.1 Glaucoma151
      2.3.2.2 Age-Related Macular Degeneration151
      2.3.2.3 Diabetic Macular Edema161
      2.3.2.4 Diabetic Retinopathy171
      2.3.2.5 Dry Eye Syndrome171
  2.4 Co-morbidities and Complications181
  2.5 Epidemiology Patterns; Prevalence, Patient Segmentation, and Diagnostic and Treatment Usage Rates191
    2.5.1 Glaucoma201
    2.5.2 Age-Related Macular Degeneration211
    2.5.3 Diabetic Macular Edema221
    2.5.4 Diabetic Retinopathy222
    2.5.5 Dry Eye Syndrome242
  2.6 Treatment263
3 Key Marketed Products299
  3.1 Overview291
  3.2 Lucentis (ranibizumab)291
  3.3 Eylea (aflibercept)301
  3.4 Avastin (bevacizumab)311
  3.5 Restasis (cyclosporine)322
  3.6 Alphagan (brimonidine tartrate)341
  3.7 Lumigan (bimatoprost)351
  3.8 Xalatan (latanoprost)362
4 Pipeline Landscape Assessment3823
  4.1 Overview381
  4.2 Pipeline Development Landscape383
  4.3 Mechanisms of Action in the Pipeline413
  4.4 Clinical Trials441
    4.4.1 Failure Rate441
      4.4.1.1 Indication451
      4.4.1.2 Molecule Type461
      4.4.1.3 Mechanism of Action471
    4.4.2 Clinical Trial Duration481
      4.4.2.1 Indication491
      4.4.2.2 Molecule Type501
      4.4.2.3 Mechanism of Action511
    4.4.3 Clinical Trial Size521
      4.4.3.1 Indication531
      4.4.3.2 Molecule Type541
      4.4.3.3 Mechanism of Action551
    4.4.4 Aggregate Clinical Program Size561
      4.4.4.1 Indication571
      4.4.4.2 Molecule Type581
      4.4.4.3 Mechanism of Action591
    4.4.5 Conclusion601
5 Multi-Scenario Market Forecast to 20226111
  5.1 Overall Market Size611
  5.2 Generic Penetration621
  5.3 Revenue Forecast by Molecular Target631
    5.3.1 Angiogenesis Inhibitors (VEGF/PlGF/PDGF Inhibitors)631
    5.3.2 Antihistamines (H1 Receptor)641
    5.3.3 Anti-inflammatories (Glucocorticoid Receptor/IL-1 Receptor/Prostaglandin Receptor)651
    5.3.4 IOP-Lowering (Prostaglandins/Beta Blockers/Rho Kinase Signaling Pathway)661
    5.3.5 Assessment of Key Pipeline Products661
      5.3.5.1 Fovista Ophthotech661
      5.3.5.2 Drug Forecast671
      5.3.5.3 SPK-RPE65 Spark Therapeutics671
      5.3.5.4 Drug Forecast671
      5.3.5.5 Lampalizumab Roche681
      5.3.5.6 Drug Forecast691
      5.3.5.7 Rhopressa Aerie Pharmaceuticals691
      5.3.5.8 Drug Forecast691
      5.3.5.9 Roclatan Aerie Pharmaceuticals701
      5.3.5.10 Drug Forecast711
6 Company Analysis and Positioning7217
  6.1 Revenue and Market Share Analysis by Company735
    6.1.1 Novartis Will Pipeline Product Approvals Offset the Patent Expiry of Lucentis?781
    6.1.2 Bayer Growing Revenues for Eylea Set to Increase Bayer s Revenue791
    6.1.3 Regeneron Growing Revenues for Eylea Will Make it the Top Selling Ophthalmology Drug801
    6.1.4 Roche Gradual Decline in Revenues Due to Lucentis Patent Expiries and Uptake of Generics811
    6.1.5 Ophthotech Pipeline Product Approval will Result in Blockbuster Status Within the Forecast Period821
    6.1.6 Spark Therapeutics Pipeline Product Approval to Resulting in Large Revenues in a Short Space of Time831
    6.1.7 Santen Patent Expiration of Eylea to Cause Gradual Decline in Revenue832
  6.2 Company Landscape851
  6.3 Marketed and Pipeline Portfolio Analysis863
7 Strategic Consolidations8911
  7.1 Licensing Deals891
    7.1.1 Deals by Region, Year and Value892
    7.1.2 Deals by Stage of Development and Value911
    7.1.3 Deals by Molecule Type, Mechanism of Action and Value922
    7.1.4 Table for Licensing Deals Valued Above $100m941
  7.2 Co-development Deals951
    7.2.1 Deals by Region, Year and Value952
    7.2.2 Deals by Stage of Development and Value971
    7.2.3 Deals by Molecule Type, Mechanism of Action and Value981
    7.2.4 Table for Co-development Deals Valued Above $100m991
8 Appendix10051
  8.1 References1008
  8.2 Table of All Clinical Stage Pipeline Products10839
  8.3 Abbreviations1471
  8.4 Disease List1471
  8.5 Methodology1482
    8.5.1 Coverage1481
    8.5.2 Secondary Research1481
    8.5.3 Market Size and Revenue Forecasts1481
    8.5.4 Pipeline Analysis1491
    8.5.5 Competitive Landscape1491
  8.6 Contact Us1501
  8.7 Disclaimer1501

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Cite this Report

  
MLA:
GBI Research Reports. "Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period" Aug 01, 2016. Alacra Store. Apr 25, 2024. <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Global-Ophthalmology-Drugs-Market-to-2022-Angiogenesis-Modulators-and-Gene-Therapies-to-Boost-Overall-Revenue-within-the-Forecast-Period-2115-729>
  
APA:
GBI Research Reports. (2016). Global Ophthalmology Drugs Market to 2022 - Angiogenesis Modulators and Gene Therapies to Boost Overall Revenue within the Forecast Period Aug 01, 2016. New York, NY: Alacra Store. Retrieved Apr 25, 2024 from <http://www.alacrastore.com/storecontent/GBI-Research-Reports/Global-Ophthalmology-Drugs-Market-to-2022-Angiogenesis-Modulators-and-Gene-Therapies-to-Boost-Overall-Revenue-within-the-Forecast-Period-2115-729>
  
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