Sections
Title | Starting Page | Number of Pages |
---|
GBIHC393MR- Schizophrenia and Associated Indications | 1 | 73 |
1 Table of Contents | 2 | 3 |
1.1 List of Tables | 3 | 1 |
1.2 List of Figures | 3 | 2 |
2 Executive Summary | 5 | 1 |
2.1 A Complex and Poorly Understood Disorder, with Numerous Unmet Needs | 5 | 1 |
2.2 Small Pipeline for Schizophrenia with Few Signs of Innovation | 5 | 1 |
2.3 Extensive Pipeline for Associated Indications | 5 | 1 |
3 The Case for Innovation | 6 | 3 |
3.1 Growing Opportunities for Biologic Products | 7 | 1 |
3.2 Diversification of Molecular Targets | 7 | 1 |
3.3 Innovative First-in-Class Product Developments Remain Attractive | 7 | 1 |
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation | 8 | 1 |
3.5 GBI Research Report Guidance | 8 | 1 |
4 Clinical and Commercial Landscape | 9 | 9 |
4.1 Disease Overview | 9 | 1 |
4.2 Epidemiology | 9 | 1 |
4.3 Disease Etiology | 9 | 1 |
4.4 Disease Pathophysiology | 10 | 1 |
4.4.1 Susceptibility Genes | 10 | 1 |
4.4.2 Neurotransmission Alterations | 11 | 1 |
4.4.3 Phosphatidylinositol Signaling | 11 | 1 |
4.5 Disease Symptoms | 11 | 1 |
4.6 Indications Associated With Schizophrenia | 11 | 1 |
4.6.1 Panic Disorder | 11 | 1 |
4.6.2 Depression | 12 | 1 |
4.6.3 Post-Traumatic Stress Disorder | 13 | 1 |
4.6.4 Obsessive Compulsive Disorder | 13 | 1 |
4.6.5 Cognitive Impairment | 13 | 1 |
4.7 Diagnosis | 14 | 1 |
4.8 Prognosis | 15 | 1 |
4.9 Treatment Options | 15 | 1 |
4.10 Overview of Marketed Products | 16 | 1 |
4.10.1 Molecule Type and Target Analysis | 16 | 1 |
4.11 Current Unmet Needs | 17 | 1 |
5 Assessment of Pipeline Product Innovation | 18 | 14 |
5.1 Schizophrenia Pipeline by Molecule Type, Phase and Therapeutic Target | 18 | 4 |
5.2 Comparative Distribution of Programs between Schizophrenia Disease Market and Pipeline by Therapeutic Target Family | 22 | 1 |
5.3 First-in-Class Pipeline Programs | 23 | 9 |
6 Schizophrenia Pathophysiology and Innovation Alignment | 32 | 5 |
6.1 The Complexity of Signaling Networks in the Central Nervous System | 32 | 1 |
6.2 First-in-Class Target Matrix Assessment | 32 | 5 |
7 First-in-Class Target Evaluation | 37 | 17 |
7.1 Pipeline Programs Targeting D-Amino Acid Oxidase | 37 | 1 |
7.2 Pipeline Programs Targeting Gamma-Aminobutyric Acid Receptor, Subunit Alpha 5 | 38 | 2 |
7.3 Pipeline Programs Targeting Glutamate Carboxypeptidase 2 | 40 | 1 |
7.4 Pipeline Programs Targeting Phosphodiesterase 9 | 41 | 2 |
7.5 Pipeline Programs Targeting Potassium Voltage-Gated Channel Subfamily C, Member 1 | 43 | 1 |
7.6 Pipeline Programs Targeting Probable G Protein-Coupled Receptor 52 | 44 | 1 |
7.7 Pipeline Programs Targeting G Protein-Coupled Receptor 78 | 45 | 1 |
7.8 Pipeline Programs Targeting Probable G Protein-Coupled Receptor 85 | 46 | 1 |
7.8.1 Pipeline Programs Targeting Pipeline Programs Targeting Probable G Protein-Coupled Receptor 173 | 47 | 1 |
7.8.2 Pipeline Programs Targeting Pipeline Programs Targeting Probable G Protein-Coupled Receptor 27 | 48 | 1 |
7.9 Pipeline Programs Targeting Sodium and Chloride Dependent Glycine Transporter 1 | 49 | 2 |
7.10 Pipeline Programs Targeting Trace Amine-Associated Receptor 1 | 51 | 1 |
7.11 Conclusion | 52 | 2 |
8 Deals and Strategic Consolidations | 54 | 11 |
8.1 Licensing Deals | 55 | 5 |
8.2 Co-development Deals | 60 | 4 |
8.3 First-in-Class Programs not Involved in Licensing or Co-development Deals | 64 | 1 |
9 Appendix | 65 | 9 |
9.1 Abbreviations | 65 | 1 |
9.2 Bibliography | 65 | 6 |
9.3 Research Methodology | 71 | 1 |
9.4 Secondary Research | 71 | 3 |
9.4.1 Marketed Product Heatmaps and Treatment Algorithm | 72 | 1 |
9.4.1.1 Market Analysis | 72 | 1 |
9.4.2 Pipeline Analysis | 72 | 1 |
9.4.2.1 Overall Pipeline | 72 | 1 |
9.4.2.2 First-in-Class Analysis | 72 | 1 |
9.4.3 First-in-Class Matrix Assessment | 72 | 1 |
9.4.4 First-in-Class Target Profiles | 72 | 1 |
9.4.5 Licensing and Co-development Deals | 73 | 1 |
9.5 Contact Us | 73 | 1 |
9.6 Disclaimer | 73 | 1 |