This report does not constitute a rating action. MILAN (S&P Global Ratings) April 20, 2022--S&P Global Ratings today said that the upcoming acquisitions of Belgium-based investment holding company Groupe Bruxelles Lambert S.A. (GBL; A+/Stable/--) will reduce its financial flexibility. GBL plans to invest up to €1 billion of equity in Netherlands-based health care company Affidea B.V. (B+/Negative/--) and spend up to €750 million to acquire a majority stake in Germany-based ophthalmology clinic specialist Sanoptis Gmbh (unrated). At end-2021 GBL had an adjusted loan to value (LTV) of 11.6%, including adjustments for €742 million of investment commitments at Sienna Capital, as well as €1,348 million of debt toward Webhelp?s minority shareholders. Pro-forma these acquisitions, GBL?s LTV will increase to about 17.7%,